This study investigated whether the smokinginducible cytochrome P450 (CYP) 1A2 and the
polymorphic CYP2D6 play significant roles in the metabolism of olanzapine and its clinical …

CYP1A2 polymorphism has been well studied in white persons and Asians but not in Africans.
We performed CYP1A2 genotype and phenotype analysis using caffeine in Ethiopians …

Caffeine from dietary sources (mainly coffee, tea and soft drinks) is the most frequently and
widely consumed CNS stimulant in the world today. Because of its enormous popularity, the …

Twenty-five healthy volunteers were given 100 mg caffeine orally and several estimates of
cytochrome P450 1A2 (CYP1A2) activity were evaluated. The validation was performed by …

Genetic factors contribute to the phenotype of drug response, but the translation of
pharmacogenetic outcomes into drug discovery, drug development or clinical practice has proved to …

The isozymes CYP1A2, CYP2D6, and CYP3A4/5 are involved in the majority of all cytochrome
P450– mediated drug biotransformations. In this study we investigated the inhibition …

BACKGROUND. P‐glycoprotein (P‐gp) is a transmembrane transporter that is encoded by
the adenosine triphosphate‐binding cassette B1 (ABCB1) (multidrug resistance 1) gene, …

Background Fluvoxamine is a selective serotonin reuptake inhibitor used widely in the
treatment of depression and other psychiatric diseases, but little is known about the specific …

Objectives Fluvoxamine is metabolized by the polymorphic cytochrome P450 (CYP) 2D6
and the smoking‐inducible CYP1A2. Therapeutic doses of fluvoxamine inhibit both CYP1A2 …

We have investigated several factors that might be related to the occurrence of toxic effects
during the performance of a urinary test with caffeine (300 mg po), in 120 healthy volunteers. …