Comparative pharmacology of rat and human α7 nAChR conducted with net charge analysis

RL Papke, JK Porter Papke - British journal of pharmacology, 2002 - Wiley Online Library
Pharmacological studies of α7 nicotinic acetylcholine receptors are confounded by the fact
that rapid desensitization to high agonist concentration causes α7 peak responses to occur …

Hydroxy metabolites of the Alzheimer's drug candidate 3-[(2, 4-dimethoxy) benzylidene]-anabaseine dihydrochloride (GTS-21): their molecular properties, interactions …

…, K Wildeboer, K Prokai-Tatrai, J Porter-Papke… - Molecular …, 2004 - ASPET
3-[(2,4-Dimethoxy)benzylidene]-anabaseine dihydrochloride (DMXBA; GTS-21), an
Alzheimer's drug candidate, selectively stimulates α7 nicotinic acetylcholine receptors. It rapidly …

[CITATION][C] Exploring social, regional, and ethnic variation in the undergraduate classroom

D Durian, JP Papke, S Sampson - American Speech, 2009 - read.dukeupress.edu
As researchers of language variation and sociolinguistics, we are consciously aware of the
extent to which variation is all around us. As teachers in the undergraduate classroom, we …

Order in Sanskrit Preverbs

JP Papke - Main Theme: Variation and Change in Morphology - academia.edu
In Classical Sanskrit, numerous verbal prefixes (‘preverbs’) combine with verbs to give new
meanings (gam ‘go’‚versus sam+ gam ‘accompany’). The phenomenon is not unique to …

Activity of α7-selective agonists at nicotinic and serotonin 5HT3 receptors expressed in Xenopus oocytes

RL Papke, JKP Papke, GM Rose - Bioorganic & medicinal chemistry letters, 2004 - Elsevier
Nicotinic receptors containing α7 subunits are widely distributed in the central nervous system
and are thought to be involved in a number of functions. However, it has been difficult to …

The structural basis for GTS-21 selectivity between human and rat nicotinic α7 receptors

C Stokes, JKP Papke, NA Horenstein, WR Kem… - Molecular …, 2004 - ASPET
The α7 nAChR-selective partial agonist 3-(2,4-dimethoxybenzylidene)anabaseine (GTS-21)
is more efficacious and potent for rat receptors than for human α7 receptors. Four single …

Effects at a distance in α7 nAChR selective agonists: benzylidene substitutions that regulate potency and efficacy

RL Papke, EM Meyer, S Lavieri, SR Bollampally… - …, 2004 - Elsevier
Anabaseine is a marine worm toxin that is a relatively non-selective nicotinic agonist, activating
both muscle-type and neuronal nicotinic acetylcholine receptors (nAChR) with varying …

Classical Sanskrit preverb ordering: a diachronic study

JKP Papke - 2010 - rave.ohiolink.edu
The Indo-European language family contains many'small words' with various adverbial
meanings and functions, including preverbs. The term'preverb'is used to label any of a variety of …

[PDF][PDF] Use of net charge analysis for the study of ion channel pharmacology

RL Papke, JKP Papke - AxoBits, 2002 - Citeseer
Concentration-response studies are the keystone of ion channel pharmacology. For
example, to characterize an experimental agonist, responses to the drug are compared to …

The effects of subunit composition on the inhibition of nicotinic receptors by the amphipathic blocker 2, 2, 6, 6-tetramethylpiperidin-4-yl heptanoate

RL Papke, JD Buhr, MM Francis, KI Choi… - Molecular …, 2005 - ASPET
The therapeutic targeting of nicotinic receptors in the brain will benefit from the identification
of drugs that may be selective for their ability to activate or inhibit a limited range of nicotine …