Redox-dependent mechanisms in coronary collateral growth: the “redox window” hypothesis

J Yun, P Rocic, YF Pung, S Belmadani… - Antioxidants & redox …, 2009 - liebertpub.com
This review addresses the complexity of coronary collateral growth from the aspect of redox
signaling and introduces the concept of a “redox window” in the context of collateral growth. …

Structural basis of receptor/G protein coupling selectivity studied with muscarinic receptors as model systems

J Wess, J Liu, N Blin, J Yun, C Lerche, E Kostenis - Life sciences, 1997 - Elsevier
Different muscarinic acetylcholine receptor subtypes were used as model systems to study
the structural basis of receptor/G protein coupling selectivity. Extensive mutagenesis studies …

Identification of a receptor/G-protein contact site critical for signaling specificity and G-protein activation.

J Liu, BR Conklin, N Blin, J Yun… - Proceedings of the …, 1995 - National Acad Sciences
Each G protein-coupled receptor recognizes only a distinct subset of the many structurally
closely related G proteins expressed within a cell. How this selectively is achieved at a …

Vitamin B12 and Redox Homeostasis: Cob(II)alamin Reacts with Superoxide at Rates Approaching Superoxide Dismutase (SOD)

E Suarez-Moreira, J Yun, CS Birch… - Journal of the …, 2009 - ACS Publications
We report a kinetic study of the reaction between superoxide and an important intracellular
form of vitamin B 12 , cob(II)alamin. Superoxide is implicated in the pathophysiology of many …

Vitamin B12 protects against superoxide-induced cell injury in human aortic endothelial cells

ES Moreira, NE Brasch, J Yun - Free Radical Biology and Medicine, 2011 - Elsevier
Superoxide (O 2 •− ) is implicated in inflammatory states including arteriosclerosis and
ischemia–reperfusion injury. Cobalamin (Cbl) supplementation is beneficial for treating many …

[HTML][HTML] In vitro and in vivo studies of antagonistic effects of human growth hormone analogs.

WY Chen, NY Chen, J Yun, TE Wagner… - Journal of Biological …, 1994 - Elsevier
A bovine growth hormone (bGH) analog, bGH-G119R, has been shown to act as a functional
antagonist of GH activity both in vitro and in vivo. In the present study, human (h) GH …

[HTML][HTML] Mapping of Single Amino Acid Residues Required for Selective Activation of Gq/11 by the m3 Muscarinic Acetylcholine Receptor (∗)

N Blin, J Yun, J Wess - Journal of Biological Chemistry, 1995 - ASBMB
Each G protein-coupled receptor can interact only with a limited number of the many structurally
similar G proteins expressed within a cell. This study was undertaken to identify single …

Aminoglycoside-mediated rescue of a disease-causing nonsense mutation in the V2 vasopressin receptor gene in vitro and in vivo

K Sangkuhl, A Schulz, H Römpler, J Yun… - Human molecular …, 2004 - academic.oup.com
Many human diseases are caused by inactivating mutations in specific G-protein-coupled
receptors (GPCRs). In about 10% of these cases, a premature stop codon leads to the …

[HTML][HTML] Generation and phenotype of mice harboring a nonsense mutation in the V2 vasopressin receptor gene

J Yun, T Schöneberg, J Liu, A Schulz… - The Journal of …, 2000 - Am Soc Clin Investig
The V2 vasopressin receptor (V2R) plays a key role in the maintenance of a normal body
water balance. To generate an in vivo model that allows the physiological and molecular …

Functional rescue of mutant V2 vasopressin receptors causing nephrogenic diabetes insipidus by a co‐expressed receptor polypeptide.

T Schoneberg, J Yun, D Wenkert, J Wess - The EMBO Journal, 1996 - embopress.org
Inactivating mutations in distinct G protein‐coupled receptors (GPCRs) are currently being
identified as the cause of a steadily growing number of human diseases. Based on previous …