Membrane hyperpolarization inhibits agonist‐induced synthesis of inositol 1, 4, 5‐trisphosphate in rabbit mesenteric artery.
T Itoh, N Seki, S Suzuki, S Ito, J Kajikuri… - The Journal of …, 1992 - Wiley Online Library
1. Effects of membrane hyperpolarization induced by pinacidil on Ca2+ mobilization induced
by noradrenaline (NA) were investigated by measuring intracellular Ca2+ concentration ([…
by noradrenaline (NA) were investigated by measuring intracellular Ca2+ concentration ([…
Randomized controlled trial of the effect of short-term coadministration of methylcobalamin and folate on serum ADMA concentration in patients receiving long-term …
…, A Ito, J Yamamoto, T Nishio, J Kajikuri… - American journal of …, 2010 - Elsevier
BACKGROUND: Serum asymmetric dimethylarginine (ADMA) levels are increased in
maintenance hemodialysis patients, and this abnormality may increase cardiovascular risk. We …
maintenance hemodialysis patients, and this abnormality may increase cardiovascular risk. We …
[HTML][HTML] Downregulation of IL-8 and IL-10 by the Activation of Ca2+-Activated K+ Channel KCa3.1 in THP-1-Derived M2 Macrophages
S Ohya, M Matsui, J Kajikuri, H Kito, K Endo - International journal of …, 2022 - mdpi.com
THP-1-differentiated macrophages are useful for investigating the physiological significance
of tumor-associated macrophages (TAMs). In the tumor microenvironment (TME), TAMs with …
of tumor-associated macrophages (TAMs). In the tumor microenvironment (TME), TAMs with …
[HTML][HTML] KCa1.1 K+ Channel Inhibition Overcomes Resistance to Antiandrogens and Doxorubicin in a Human Prostate Cancer LNCaP Spheroid Model
S Ohya, J Kajikuri, K Endo, H Kito, M Matsui - International Journal of …, 2021 - mdpi.com
Several types of K + channels play crucial roles in tumorigenicity, stemness, invasiveness,
and drug resistance in cancer. Spheroid formation of human prostate cancer (PC) LNCaP …
and drug resistance in cancer. Spheroid formation of human prostate cancer (PC) LNCaP …
Ca2+‐activated K+ channel KCa1.1 as a therapeutic target to overcome chemoresistance in three‐dimensional sarcoma spheroid models
S Ohya, J Kajikuri, K Endo, H Kito, EE Elboray… - Cancer …, 2021 - Wiley Online Library
The large‐conductance Ca 2+ ‐activated K + channel K Ca 1.1 plays a pivotal role in tumor
development and progression in several solid cancers. The three‐dimensional (3D) in vitro …
development and progression in several solid cancers. The three‐dimensional (3D) in vitro …
Reduced function of endothelial prostacyclin in human omental resistance arteries in pre‐eclampsia
Y Suzuki, T Hattori, J Kajikuri… - The Journal of …, 2002 - Wiley Online Library
It remains unclear in pre‐eclampsia whether or not a functional change occurs in the role
played by prostacyclin in endothelium‐dependent relaxation in resistance arteries. We …
played by prostacyclin in endothelium‐dependent relaxation in resistance arteries. We …
[HTML][HTML] Transcriptional Repression and Protein Degradation of the Ca2+-Activated K+ Channel KCa1.1 by Androgen Receptor Inhibition in Human Breast Cancer …
…, M Kawaguchi, M Fujimoto, M Ri, J Kajikuri… - Frontiers in …, 2018 - frontiersin.org
The large-conductance Ca 2+ -activated K + channel K Ca 1.1 plays an important role in the
promotion of breast cancer cell proliferation and metastasis. The androgen receptor (AR) is …
promotion of breast cancer cell proliferation and metastasis. The androgen receptor (AR) is …
Reduced hyperpolarization in endothelial cells of rabbit aortic valve following chronic nitroglycerine administration
N Kusama, J Kajikuri, T Yamamoto… - British journal of …, 2005 - Wiley Online Library
This study was undertaken to determine whether long‐term in vivo administration of nitroglycerine
(NTG) downregulates the hyperpolarization induced by acetylcholine (ACh) in aortic …
(NTG) downregulates the hyperpolarization induced by acetylcholine (ACh) in aortic …
[HTML][HTML] Sarpogrelate hydrochloride reduced intimal hyperplasia in experimental rabbit vein graft
…, K Komori, K Hattori, D Yamanouchi, J Kajikuri… - Journal of vascular …, 2009 - Elsevier
OBJECTIVES: The selective 5-HT 2A receptor antagonist sarpogrelate has been clinically
used for treatment in atherosclerotic diseases. However, it remains unknown whether …
used for treatment in atherosclerotic diseases. However, it remains unknown whether …
Transcriptional repression of human epidermal growth factor receptor 2 by ClC‐3 Cl−/H+ transporter inhibition in human breast cancer cells
M Fujimoto, H Kito, J Kajikuri, S Ohya - Cancer Science, 2018 - Wiley Online Library
Recent studies have indicated that the intracellular concentration of chloride ions (Cl − )
regulates gene expression in several types of cells and that Cl − modulators positively or …
regulates gene expression in several types of cells and that Cl − modulators positively or …