Background: CYP2C9 polymorphisms are associated with decreased S-warfarin clearance
and lower maintenance dosage. Decreased expression of VKORC1 resulting from the −…

The ability of deoxycytidine kinase (dCK) to phosphorylate 2’-deoxycytidine(dCyd) and its
analogs in the presence of eight nucleoside triphosphates(NTP5), simulating the cellular milieu…

In managing pain, clinicians working with the more than 80 million people in the United States
who suffer annually from serious pain face decisions about choosing the most appropriate …

Warfarin is the most commonly prescribed oral anticoagulant for the treatment and prevention
of thromboembolic events. The correct maintenance dose of warfarin for a given patient is …

We performed a randomised pilot trial of PerMIT, a novel decision support tool for genotype-based
warfarin initiation and maintenance dosing, to assess its efficacy for improving …

Methods Searches were performed with PubMed and Google Scholar by using searches
combining “pharmacogenomics” with “schizophrenia,”“psychosis,”“major depression,”“bipolar,”“…

Background: The application of pharmacogenetic results requires demonstrable correlations
between a test result and an indicated specific course of action. We developed a …

Deoxycytidine kinase is the rate-limiting process in the activation for several clinically
important antitumor agents. Previous studies have focused on deoxycytidine (dCyd) and …

Considerable progress has been made in pharmacogenetics over the past decade, resulting
in increased awareness and availability of pharmacogenetic diagnostics in the clinical …

Virtually all infants with achondroplasia exhibit variably severe hypotonia in infancy. This
hypotonia contributes to delays in motor development and risks for sudden death. Some have …