[HTML][HTML] Selective LRRK2 kinase inhibition reduces phosphorylation of endogenous Rab10 and Rab12 in human peripheral mononuclear blood cells

K Thirstrup, JC Dächsel, FS Oppermann… - Scientific reports, 2017 - nature.com
Genetic variation in the leucine-rich repeat kinase 2 (LRRK2) gene is associated with risk of
familial and sporadic Parkinson’s disease (PD). To support clinical development of LRRK2 …

[HTML][HTML] Chronic treatment with 17-DMAG improves balance and coordination in a new mouse model of Machado-Joseph disease

…, M Amorim, C Soares-Cunha, P Oliveira, K Thirstrup… - …, 2014 - Elsevier
Machado-Joseph disease (MJD) or spinocerebellar ataxia type 3 (SCA3) is a neurodegenerative
disease currently with no treatment. We describe a novel mouse model of MJD which …

Evidence for a pancreatic lipase subfamily with new kinetic properties

K Thirstrup, R Verger, F Carriere - Biochemistry, 1994 - ACS Publications
… chromatography as previously described for recombinant HPL (Thirstrup et al., 1993). The
purity … A classical pancreatic lipase is also found in the coypu (Thirstrup et al., manuscript in …

The Imprinted Gene Neuronatin Is Regulated by Metabolic Status and Associated With Obesity

…, V Vatin, JD Mikkelsen, K Thirstrup… - …, 2010 - Wiley Online Library
Using restriction fragment differential display (RFDD) technology, we have identified the
imprinted gene neuronatin (Nnat) as a hypothalamic target under the influence of leptin. Nnat …

Conversion of agonist site to metal-ion chelator site in the β2-adrenergic receptor

CE Elling, K Thirstrup, B Holst… - Proceedings of the …, 1999 - National Acad Sciences
Previously metal-ion sites have been used as structural and functional probes in seven
transmembrane receptors (7TM), but as yet all the engineered sites have been inactivating. …

Discovery and SAR of a series of agonists at orphan G protein-coupled receptor 139

F Shi, JK Shen, D Chen, K Fog, K Thirstrup… - ACS Medicinal …, 2011 - ACS Publications
GPR139 is an orphan G-protein coupled receptor (GPCR) which is primarily expressed in
the central nervous system (CNS). In order to explore the biological function of this receptor, …

Endogenous 2-oxoglutarate levels impact potencies of competitive HIF prolyl hydroxylase inhibitors

K Thirstrup, S Christensen, HA Møller, A Ritzén… - Pharmacological …, 2011 - Elsevier
… the K m of 2-OG toward the HPH2 enzyme was determined to 0.4 μM. This is in accordance
with a previous reported K m … the K m for a substrate or co-factor can be determined from K m …

Design of leucine-rich repeat kinase 2 (LRRK2) inhibitors using a crystallographic surrogate derived from checkpoint kinase 1 (CHK1)

…, AE Surgenor, L Terry, K Thirstrup… - Journal of medicinal …, 2017 - ACS Publications
Mutations in leucine-rich repeat kinase 2 (LRRK2), such as G2019S, are associated with an
increased risk of developing Parkinson’s disease. Surrogates for the LRRK2 kinase domain …

Pancreatic lipase structure− function relationships by domain exchange

F Carrière, K Thirstrup, S Hjorth, F Ferrato… - Biochemistry, 1997 - ACS Publications
We designed chimeric mutants by exchanging the lid domains of the classical human
pancreatic lipase (HPL) and the guinea pig pancreatic lipase related protein 2 (GPLRP2). This …

Nest building performance following MPTP toxicity in mice

…, J Kirchhoff, A Mørk, J Van Beek, K Thirstrup… - Behavioural brain …, 2010 - Elsevier
Systemic injection of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) in mice is one of
the primary models used to evaluate neuroprotective and symptomatic treatment strategies …