The use of pharmacoepidemiology to study beneficial drug effects

BL Strom, KL Melmon - Pharmacoepidemiology, 2012 - Wiley Online Library
In order to be approved for marketing in the United States, drugs must be proven to be safe
and effective using “adequate and well‐controlled investigations.” This chapter clarifies the …

Lindau's disease: review of the literature and study of a large kindred

KL Melmon, SW Rosen - The American journal of medicine, 1964 - Elsevier
The history of Lindau's disease is reviewed, and current knowledge of the multisystemic
involvement and the clinical, laboratory and roentgenologic features are outlined. Ten proved …

Generation of antigen-specific suppressor cells during allergy desensitization

…, AL Sheffer, DK Greineder, KL Melmon - New England Journal …, 1980 - Mass Medical Soc
We used a suppressor-cell assay to study a possible mechanism of allergy desensitization.
Before specific immunotherapy, blood mononuclear cells from 20 patients with ragweed …

Lidocaine pharmacokinetics in advanced heart failure, liver disease, and renal failure in humans

PD THOMSON, KL MELMON… - Annals of Internal …, 1973 - acpjournals.org
The pharmacokinetics of intravenously administered lidocaine were studied in 10 normal
subjects, 11 patients with heart failure, 8 patients with alcoholic liver disease, and 6 chronic …

Modelling of individual pharmacokinetics for computer-aided drug dosage

LB Sheiner, B Rosenberg, KL Melmon - Computers and Biomedical …, 1972 - Elsevier
A conceptual scheme and associated statistical methodology is presented which is designed
to provide the basis for a clinically useful computer program to suggest optimal dosage …

Fatty acid amides of ethanol-amine in mammalian tissues.

NR Bachur, K Masek, KL Melmon… - Journal of Biological …, 1965 - cabdirect.org
Palmitoylethanolamide was found in brain, liver and skeletal muscle of fasting rats and
guineapigs but not in lung, heart, spleen, intestine, kidney or blood. In brain it represented …

Lidocaine disposition kinetics in monkey and man; I. Prediction by a perfusion model

N Benowitz, RP Forsyth, KL Melmon… - Clinical Pharmacology …, 1974 - Wiley Online Library
Lidocaine pharmacokinetics are described in the unanesthetized restrained rhesus monkey
after bolus and steady infusion. Simultaneous measurements of systemic and regional …

Beta-adrenergic receptors on human suppressor, helper, and cytolytic lymphocytes

…, ED Silverman, EG Engleman, KL Melmon - Biochemical …, 1986 - Elsevier
Using the radioligand beta-adrenergic blocker [ 125 I]cyanopindolol (ICYP), we have
characterized the beta-adrenergic receptors on Leu 3 + (T helper [T H ]), Leu 2 + , 9.3 − (T …

Preventable drug reactions—causes and cures

KL Melmon - New England Journal of Medicine, 1971 - Mass Medical Soc
MODERN therapeutic agents have contributed favorably to the physician's ability to influence
the course of many diseases. Their use has also created a formidable health problem: 18 …

Developmental changes in constriction of the ductus arteriosus: responses to oxygen and vasoactive agents in the isolated ductus arteriosus of the fetal lamb

…, MA Heymann, AM Rudolph, KL Melmon - Pediatric …, 1972 - nature.com
Extract: Development of the constrictor response of the ductus arteriosus to O 2 and selected
vasoactive drugs (acetylcholine and bradykinin) was studied in 20 fetal lambs weighing 680…