The greater affinity of electrophiles for thiol groups than for hydroxyl or amine groups provides
a teleological basis for the evolution of this mechanism to assist in the maintenance of …

Many solid tumors contain substantial fractions of hypoxic cells which are relatively resistant
to both radiation therapy and certain cytotoxic drugs. We have previously shown that …

We have shown previously that tumor cell resistance to cisplatin is associated with elevated
intracellular levels of glutathione, which is accomplished at least in part by increased …

PURPOSE: Raf-1 is a protein kinase that plays a broad role in oncogenic signaling and acts
as a downstream effector of Ras in the mitogen-activated protein kinase pathway. The …

Angiogenesis inhibition has been shown to enhance the therapeutic efficacy of cytotoxic
chemotherapy in colorectal cancer. The basis of the contribution of this modality has not been …

Background: Recent evidence indicates that programmed cell death or apoptosis may be
an important mechanism for the lethality of cancer chemotherapy drugs in tumor cells. …

The activity of the two-electron bioreductive enzyme DT-diaphorase (DTD) is induced by
heat shock, hypoxic stress, oltipraz, and mitomycin C (MMC). Transcriptional induction is …

Prolonged exposure to mutagenic substances is strongly associated with an individual's risk
of developing colorectal cancer. Clinical investigation of oltipraz as a chemopreventive …

Abnormally regulated signaling through proliferative signal transduction pathways characterizes
many of the common solid tumors. The best described of these involves potentially …

Human ovarian cancer cell lines derived from A2780 by stepwise exposure to increasing
cisplatin concentrations show progressive resistance to cisplatin. Previous studies have shown …