User profiles for Karl Sward
Karl SwärdProfessor of Physiology, Lund University Verified email at med.lu.se Cited by 17912 |
Deletion of the G protein-coupled receptor 30 impairs glucose tolerance, reduces bone growth, increases blood pressure, and eliminates estradiol-stimulated insulin …
UEA Mårtensson, SA Salehi, S Windahl… - …, 2009 - academic.oup.com
In vitro studies suggest that the G protein-coupled receptor (GPR) 30 is a functional estrogen
receptor. However, the physiological role of GPR30 in vivo is unknown, and it remains to be …
receptor. However, the physiological role of GPR30 in vivo is unknown, and it remains to be …
Extracellular‐matrix‐reinforced bioinks for 3D bioprinting human tissue
Recent advances in 3D bioprinting allow for generating intricate structures with dimensions
relevant for human tissue, but suitable bioinks for producing translationally relevant tissue …
relevant for human tissue, but suitable bioinks for producing translationally relevant tissue …
Cholesterol Depletion Impairs Vascular Reactivity to Endothelin-1 by Reducing Store-Operated Ca2+ Entry Dependent on TRPC1
The reactivity of the vascular wall to endothelin-1 (ET-1) is influenced by cholesterol, which
is of possible importance for the progression of atherosclerosis. To elucidate signaling steps …
is of possible importance for the progression of atherosclerosis. To elucidate signaling steps …
Cholesterol depletion disrupts caveolae and differentially impairs agonist-induced arterial contraction
K Dreja, M Voldstedlund, J Vinten… - … , and vascular biology, 2002 - Am Heart Assoc
Objective— This study assessed the role of cholesterol-rich membrane regions, including
caveolae, in the regulation of arterial contractility. Methods and Results— Rat tail artery devoid …
caveolae, in the regulation of arterial contractility. Methods and Results— Rat tail artery devoid …
The role of RhoA and Rho-associated kinase in vascular smooth muscle contraction
… Karl Swärd and David Wilson were recipients of fellowships from the Heart & Stroke
Foundation of Canada and the Alberta Heritage Foundation for Medical Research (AHFMR). Dr. …
Foundation of Canada and the Alberta Heritage Foundation for Medical Research (AHFMR). Dr. …
Inhibition of Rho‐associated kinase blocks agonist‐induced Ca2+ sensitization of myosin phosphorylation and force in guinea‐pig ileum
K Swärd, K Dreja, M Susnjar… - The Journal of …, 2000 - Wiley Online Library
Ca 2+ sensitization of smooth muscle contraction involves the small GTPase RhoA, inhibition
of myosin light chain phosphatase (MLCP) and enhanced myosin regulatory light chain (…
of myosin light chain phosphatase (MLCP) and enhanced myosin regulatory light chain (…
[HTML][HTML] Elevated glucose levels promote contractile and cytoskeletal gene expression in vascular smooth muscle via Rho/protein kinase C and actin polymerization
TT Hien, KM Turczyńska, D Dahan, M Ekman… - Journal of Biological …, 2016 - ASBMB
Both type 1 and type 2 diabetes are associated with increased risk of cardiovascular disease.
This is in part attributed to the effects of hyperglycemia on vascular endothelial and smooth …
This is in part attributed to the effects of hyperglycemia on vascular endothelial and smooth …
[HTML][HTML] The ATP receptors P2X7 and P2X4 modulate high glucose and palmitate-induced inflammatory responses in endothelial cells
Endothelial cells lining the blood vessels are principal players in vascular inflammatory
responses. Dysregulation of endothelial cell function caused by hyperglycemia, dyslipidemia, …
responses. Dysregulation of endothelial cell function caused by hyperglycemia, dyslipidemia, …
[HTML][HTML] Vascular smooth muscle–specific YAP/TAZ deletion triggers aneurysm development in mouse aorta
MA Martínez, O Ritsvall, JA Bastrup, S Celik… - JCI insight, 2023 - ncbi.nlm.nih.gov
Inadequate adaption to mechanical forces, including blood pressure, contributes to development
of arterial aneurysms. Recent studies have pointed to a mechanoprotective role of YAP …
of arterial aneurysms. Recent studies have pointed to a mechanoprotective role of YAP …
Stretch-induced contractile differentiation of vascular smooth muscle: sensitivity to actin polymerization inhibitors
…, S Albinsson, U Malmqvist, K Sward… - … of Physiology-Cell …, 2003 - journals.physiology.org
Signaling mechanisms for stretch-dependent growth and differentiation of vascular smooth
muscle were investigated in mechanically loaded rat portal veins in organ culture. Stretch-…
muscle were investigated in mechanically loaded rat portal veins in organ culture. Stretch-…