Differences in the catalytic efficiencies of allelic variants of glutathione transferase P1-1 towards carcinogenic diol epoxides of polycyclic aromatic hydrocarbons.
K Sundberg, AS Johansson, G Stenberg… - …, 1998 - academic.oup.com
Previous studies have identified allelic variants of the human glutathione transferase (GST)
Pi gene and showed that the two different encoded proteins with isoleucine (GSTP1-1/I-105) …
Pi gene and showed that the two different encoded proteins with isoleucine (GSTP1-1/I-105) …
[PDF][PDF] Introduction to in vitro estimation of metabolic stability and drug interactions of new chemical entities in drug discovery and development
P Baranczewski, A Stanczak, K Sundberg… - Pharmacological …, 2006 - if-pan.krakow.pl
Determination of metabolic properties of a new chemical entity (NCE) is one of the most
important steps during the drug discovery and development process. Nowadays, in vitro …
important steps during the drug discovery and development process. Nowadays, in vitro …
Glutathione Conjugation and DNA Adduct Formation of Dibenzo[a,l]pyrene and Benzo[a]pyrene Diol Epoxides in V79 Cells Stably Expressing Different Human …
K Sundberg, K Dreij, A Seidel… - Chemical research in …, 2002 - ACS Publications
Mammalian V79 cells stably expressing human glutathione transferase (GST) A1-1, M1-1,
and P1-1 (the allelic variant with Val105 and Ala114) have been constructed and …
and P1-1 (the allelic variant with Val105 and Ala114) have been constructed and …
Glutathione conjugation of bay-and fjord-region diol epoxides of polycyclic aromatic hydrocarbons by glutathione transferases M1-1 and P1-1
K Sundberg, M Widersten, A Seidel… - Chemical research in …, 1997 - ACS Publications
Metabolism of polycyclic aromatic hydrocarbons in mammalian cells results in the formation
of vicinal diol epoxides considered as ultimate carcinogens if the oxirane ring is located in a …
of vicinal diol epoxides considered as ultimate carcinogens if the oxirane ring is located in a …
Overexpression of stably transfected human glutathione S-transferase P1–1 protects against DNA damage by benzo [a] pyrene diol-epoxide in human T47D cells
WR Fields, CS Morrow, AJ Doss, K Sundberg… - Molecular …, 1998 - ASPET
The (+)-anti enantiomer of benzo[a]pyrene-7,8-dihydrodiol-9,10-epoxide (BPDE) is a potent
mutagenic and carcinogenic metabolite of benzo[a]pyrene (BP), and a major fraction is …
mutagenic and carcinogenic metabolite of benzo[a]pyrene (BP), and a major fraction is …
Catalytic Activities of Human Alpha Class Glutathione Transferases toward Carcinogenic Dibenzo[a,l]pyrene Diol Epoxides
K Dreij, K Sundberg, AS Johansson… - Chemical research in …, 2002 - ACS Publications
In this study, human glutathione transferases (GSTs) of alpha class have been assayed with
the ultimate carcinogenic (−)-anti- and (+)-syn-diol epoxides (DEs) derived from the …
the ultimate carcinogenic (−)-anti- and (+)-syn-diol epoxides (DEs) derived from the …
[HTML][HTML] Detoxication of carcinogenic fjord-region diol epoxides of polycyclic aromatic hydrocarbons by glutathione transferase P1-1 variants and glutathione
K Sundberg, A Seidel, B Mannervik, B Jernström - FEBS letters, 1998 - Elsevier
Epidemiological studies suggest that individuals differing in the expression of allelic variants
of the human glutathione transferase (GST) Pi gene differ in susceptibility to chemical …
of the human glutathione transferase (GST) Pi gene differ in susceptibility to chemical …
[PDF][PDF] Synthesis, NMR Spectra and Function of Peptides with a-Methylserine attached to the RGD Sequence of Osteopontin
H Mickos, K Sundberg, B Lüning - Acta Chemica Scandinavia, 1992 - actachemscand.org
Mickos, H., Sundberg, К. and Lüning, В., 1992. Synthesis, NMR Spectra and Function of
Peptides with a-Methylserine attached to the RGD Sequence of Osteopontin.-Acta Chem. Scand…
Peptides with a-Methylserine attached to the RGD Sequence of Osteopontin.-Acta Chem. Scand…
DNA ADDUCTS OF BENZO[A]PYRENE- AND DIBENZO[A,L]PYRENE-DIOL EPOXIDES IN HUMAN LUNG EPITHELIAL CELLS: KINETICS OF ADDUCT REMOVAL …
K Dreij, E Bajak, K Sundberg, I Cotgreave… - Polycyclic Aromatic …, 2004 - Taylor & Francis
The fjord-region PAH dibenzo[a,l]pyrene (DBP) is considerably more carcinogenic than the
bay-region benzo[a]pyrene (BP). This fact can be ascribed to differences in DNA binding …
bay-region benzo[a]pyrene (BP). This fact can be ascribed to differences in DNA binding …
Toxicological Characterization of a Novel in Vivo Benzo[a]pyrene Metabolite, 7-Oxo-benz[d]anthracene-3,4-dicarboxylic Acid Anhydride
…, J Nygren, J Bergman, K Sundberg… - Chemical Research …, 2002 - ACS Publications
Recently, we described a new in vivo pathway in the metabolism of benzo[a]pyrene (BP)
that involves an opening of the aromatic ring system. One of the products of this pathway, …
that involves an opening of the aromatic ring system. One of the products of this pathway, …