Discovery that the hormone erythropoietin (EPO) and its receptor play a significant biological
role in tissues outside of the hematopoietic system has fueled significant interest in EPO as …

Despite our present knowledge of some of the cellular pathways that modulate central nervous
system injury, complete therapeutic prevention or reversal of acute or chronic neuronal …

Background— Erythropoietin (EPO) is a critical regulator for the proliferation of immature
erythroid precursors, but its role as a potential cytoprotectant in the cerebrovasculature system …

We recently demonstrated that reactive astrocytes express NADPH diaphorase activity, a
marker for Nitric Oxide Synthase, following transient global ischemia (Neuroscience Letters 154…

Diabetes mellitus (DM) affects approximately 170 million individuals worldwide and is
expected to alter the lives of at least 366 million individuals within a future span of 25 years. Of …

Interest in the diverse biology of protein tyrosine phosphatases that are encoded by more
than 100 genes in the human genome continues to grow at an accelerated pace. In particular, …

Erythropoietin (EPO) plays a significant role in the hematopoietic system, but the function of
EPO as a neuroprotectant and anti‐inflammatory mediator requires further definition. We …

Nicotinamide, the amide form of vitamin B 3 (niacin), is changed to its mononucleotide
compound with the enzyme nicotinic acide/nicotinamide adenylyl-transferase, and participates in …

The release of reactive oxygen species (ROS) and the generation of oxidative stress are
considered critical factors for the pathogenesis of diabetes mellitus (DM), a disorder that is …

The mammalian target of rapamycin (mTOR), the key component of the protein complexes
mTORC1 and mTORC2, plays a critical role in cellular development, tissue regeneration, and …