Prolongation of relaxation is a hallmark of diabetic cardiomyopathy. Most studies attribute
this defect to decreases in sarco(endo)plasmic reticulum Ca 2+ -ATPase (SERCA2a) …

Diabetic hearts exhibit decreased responsiveness to stimulation byβ-adrenoreceptor (β-AR)
agonists. This decrease in activity may be due to changes in expression and/or signaling of …

Decrease in cardiac contractility is a hallmark of chronic diabetes. Previously we showed
that this defect results, at least in part, from a dysfunction of the type 2 ryanodine receptor …

The present study was undertaken to assess the effects of exercise training (ExT) initiated
after the onset of diabetes on cardiac ryanodine receptor expression and function. Type 1 …

Age-related cataracts are a leading cause of blindness. Previously, we have demonstrated
the association of the unfolded protein response with various cataractogenic stressors. …

Using biochemical/pharmacological approaches, we previously showed that type 2 ryanodine
receptors (RyR2) become dysfunctional in hearts of streptozotocin-induced type 1 diabetic …

Methylglyoxal is a cytotoxic reactive carbonyl compound produced by central metabolism.
Dedicated glyoxalases convert methylglyoxal to d-lactate using multiple catalytic strategies. In …

OBJECTIVE Approximately 25% of children and adolescents with type 1 diabetes will develop
diastolic dysfunction. This defect, which is characterized by an increase in time to cardiac …

Recent epidemiological studies confirm the prevalence of cataract in epileptic patients.
Similarly, the drugs used to treat epilepsy also show the connection with increased cataract …

It has been established that atherosclerotic coronary artery disease is more frequent and more
severe in diabetic compared to non-diabetic subjects, but the reason for the excess risk of …