Low oxygen tension influences tumor progression by enhancing angiogenesis; and histone
deacetylases (HDAC) are implicated in alteration of chromatin assembly and tumorigenesis. …

Hypoxia-inducible factor 1 (HIF-1) plays a central role in cellular adaptation to changes in
oxygen availability. Recently, prolyl hydroxylation was identified as a key regulatory event that …

Hypoxia-inducible factor (HIF-1) is an oxygen-dependent transcriptional activator, which plays
crucial roles in the angiogenesis of tumors and mammalian development. HIF-1 consists …

For 10,000 years pigs and humans have shared a close and complex relationship. From
domestication to modern breeding practices, humans have shaped the genomes of domestic …

Birds are the most species-rich class of tetrapod vertebrates and have wide relevance across
many research fields. We explored bird macroevolution using full genomes from 48 avian …

The blood-brain barrier (BBB) is essential for maintaining brain homeostasis and low
permeability. BBB maintenance is important in the central nervous system (CNS) because …

Visfatin has recently been identified as a novel visceral adipokine which may be involved in
obesity-related vascular disorders. However, it is not known whether visfatin directly …

Here we report the inhibition of cellular invasion by a recombinant mouse endostatin and the
possible mechanism of the inhibition. Endostatin significantly reduced endothelial as well …

Objectives and design Chlorogenic acid, which belongs to the polyphenols, is an anti-oxidant
and anti-obesity agent. In this study, we investigated the role of chlorogenic acid in …

A synergistic combination of two next-generation sequencing platforms with a detailed
comparative BAC physical contig map provided a cost-effective assembly of the genome …