Since the late 1950 s, extensive research efforts have been devoted to the discovery and
development of antifolate antimetabolites as chemotherapeutic agents for the management of …

N-[4-[2-(2-amino-3,4-dihydro-4-oxo-7H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]-benzoyl]-l-glutamic
acid (LY231514) is a novel pyrrolo[2,3-d]pyrimidine-based antifolate currently undergoing …

The pyrrolopyrimidine-based antifolate, N-¿ 4-[2-(2-amino-3, 4-dihydro-4-oxo-7H-pyrrolo [2,
3-d] pyrimidin-5-yl) ethyl] benzoyl¿ glutamic acid, LY231514 (MTA) has demonstrated …

We have studied the molecular effects of a LFD in a murine model in order to better define the
biochemical changes associated with folate deficiency. In addition, we have demonstrated …

The metabolism of 5, 1 0-dideazatetrahydrofolate(DDATHF [lometrexol]) to polyglutamate
derivatives by folylpoly-y-gluta-mate synthetase(FPGS) plays a central role in the activity of this …

… The pentaglutamate of Lometrexol had an ll-fold higher affinity for recombinant monofunctional
hGARFT than Lometrexol. Other groups have reported approximately 100-fold higher …

Membrane-associated folate receptors (FRs) have been detected in many mammalian species,
and multiple isoforms have been identified. The pharmacological properties of FRs from …

Mutation of the genes virA, virB, virC, and virG of the Agrobacterium tumefaciens octopine-type
Ti plasmid pTiR10 was found to cause a 100- to 10,000-fold decrease in the frequency of …

It is reported that several vir genes of the octopine-type Ti (tumour-inducing) plasmid pTiA6
of A. tumefaciens can be induced to high levels by acetosyringone in both minimal and rich …

Previous work has shown that the octopine synthase (ocs) gene encoded by the Agrobacterium
tumefaciens Ti-plasmid contains an upstream activating sequence necessary for its …