Myocardial ischemic injury results from severe impairment of coronary blood supply and
produces a spectrum of clinical syndromes. As a result of intensive investigation over decades, …

Inflammatory diseases of the aorta include routine atherosclerosis, aortitis, periaortitis, and
atherosclerosis with excessive inflammatory responses, such as inflammatory atherosclerotic …

We have speculated previously that the abrupt conversion from chronic stable to unstable
angina and the continuum to acute myocardial infarction may result from myocardial ischemia …

The major function of vascular smooth muscle cells (SMCs) is contraction to regulate blood
pressure and flow. SMC contractile force requires cyclic interactions between SMC α-actin (…

This paper collates the pathological findings from initial published autopsy reports on 23
patients with coronavirus disease 2019 (COVID-19) from 5 centers in the United States of …

Nineteen of 135 patients (four with idiopathic hemochromatosis and 131 with chronic anemia)
had cardiac iron deposits (CID). The ventricular CID were grossly visible in nine patients …

The vascular smooth muscle cell (SMC)-specific isoform of α-actin (ACTA2) is a major
component of the contractile apparatus in SMCs located throughout the arterial system. …

Apoptosis and necrosis are two fundamental types of cell death. Current knowledge
indicates that the key mechanism of apoptosis is endonuclease activation leading to …

The extracellular matrix (ECM) is a living network of proteins that maintains the structural
integrity of the myocardium and allows the transmission of electrical and mechanical forces …

Background This study assessed the effect of prolonged left ventricular unloading on native
ventricular function. Methods We reviewed data from 31 patients (30 men, 1 woman) …