Fumitremorgin C reverses multidrug resistance in cells transfected with the breast cancer resistance protein

…, DD Ross, LA Doyle, W Yang, LM Greenberger - Cancer research, 2000 - AACR
Fumitremorgin C (FTC) is a potent and specific chemosensitizing agent in cell lines selected
for resistance to mitoxantrone that do not overexpress P-glycoprotein or multidrug …

[PDF][PDF] Antibody response to SARS-CoV-2 vaccines in patients with hematologic malignancies

LM Greenberger, LA Saltzman, JW Senefeld… - Cancer cell, 2021 - cell.com
The mRNA vaccines BNT162b2 and mRNA-1273 have robust safety and efficacy against
COVID-19 among immunocompetent individuals (Creech et al., 2021). However, many …

Reversal of a novel multidrug resistance mechanism in human colon carcinoma cells by fumitremorgin C

…, E Brown, KI Collins, T Annable, LM Greenberger - Cancer research, 1998 - AACR
… Rabindran and LM Greenberger. unpublished observations. 5M. … and Greenberger. LM
P-glycoprotein mediates profound resistance to hisantrene. Oncol. Res.. 6: 291-301. 1994. 17. …

Synthesis and structure− activity relationships of 6, 7-disubstituted 4-anilinoquinoline-3-carbonitriles. The design of an orally active, irreversible inhibitor of the tyrosine …

…, R Shen, YF Wang, LM Greenberger… - Journal of medicinal …, 2003 - ACS Publications
A series of of 6,7-disubstituted-4-anilinoquinoline-3-carbonitrile derivatives that function as
irreversible inhibitors of EGFR and HER-2 kinases have been prepared. These inhibitors …

6-Substituted-4-(3-bromophenylamino) quinazolines as putative irreversible inhibitors of the epidermal growth factor receptor (EGFR) and human epidermal growth …

…, R Davis, FE Koehn, LM Greenberger… - Journal of medicinal …, 2001 - ACS Publications
A series of new 6-substituted-4-(3-bromophenylamino)quinazoline derivatives that may
function as irreversible inhibitors of epidermal growth factor receptor (EGFR) and human …

A RNA antagonist of hypoxia-inducible factor-1α, EZN-2968, inhibits tumor cell growth

LM Greenberger, ID Horak, D Filpula, P Sapra… - Molecular cancer …, 2008 - AACR
Hypoxia-inducible factor-1 (HIF-1) is a transcription factor that plays a critical role in angiogenesis,
survival, metastasis, drug resistance, and glucose metabolism. Elevated expression of …

[PDF][PDF] Anti-spike antibody response to SARS-CoV-2 booster vaccination in patients with B cell-derived hematologic malignancies

LM Greenberger, LA Saltzman, JW Senefeld… - Cancer cell, 2021 - cell.com
It has been reported that 15%–25% of patients with hematologic malignancies fail to make
anti-spike (anti-S) antibodies in response to full dosing of SARS-CoV-2 mRNA vaccines (…

4-Anilino-6, 7-dialkoxyquinoline-3-carbonitrile inhibitors of epidermal growth factor receptor kinase and their bioisosteric relationship to the 4-anilino-6, 7 …

…, DH Boschelli, MB Floyd, LM Greenberger… - Journal of medicinal …, 2000 - ACS Publications
The synthesis and SAR of a series of 4-anilino-6,7-dialkoxyquinoline-3-carbonitrile inhibitors
of epidermal growth factor receptor (EGF-R) kinase are described. Condensation of 3,4-…

Novel prodrugs of SN38 using multiarm poly (ethylene glycol) linkers

…, Y Lozanguiez, C Longley, LM Greenberger… - Bioconjugate …, 2008 - ACS Publications
CPT-11, also known as irinotecan, is a prodrug that is approved for the treatment of
advanced colorectal cancer. The active metabolite of CPT-11, SN38 (7-ethyl-10-hydroxy-…

Progesterone interacts with P-glycoprotein in multidrug-resistant cells and in the endometrium of gravid uterus

CPH Yang, SG DePinho, LM Greenberger… - Journal of Biological …, 1989 - Elsevier
P-Glycoprotein (P-GP) plays a pivotal role in maintaining the multidrug-resistant (MDR)
phenotype. This membrane glycoprotein is overproduced in MDR cells and the endometrium of …