ARONSTAM, ROBERT S., ABOOD, LEO G. & Hoss, WAYNE(1978) Influence of sulfhydryl
reagents and heavy metals on the functional state of the muscarinic acetylcholine receptor …

Human granulocytes and monocytes exhibited stereospecific, high-affinity binding to 3-quinuclidinyl
benzilate (QNB) and dihydromorphine (DHM), specific ligands for the muscarinic …

The semirigid alkaloid anatoxin a (3) 3 is known to possess high activity at the nicotinic
acetylcholine receptor. 4 Nornicotine (la), a potent agonist in its own right, has an activity …

The recently discovered nicotinic agonist pyrido [3, 4-b] homotropane (PHT) as well as its N-methyl
and 2'-meihyl derivatives (syntheses reported herein) were compared with nicotine, …

The initial finding that certain disubstituted glycolates of 3-hydroxypiperidine could elicit
potent psychotomimetic and antidepressant effects in man suggested a possible relationship …

… This posthumous publication is in memory of Leo G. Abood, Professor of Biochemistry and
Pharmacology, University of Rochester, born 1922, died 1998, and distinguished for his many …

With the recent availability of (−)-[ 3 H]nicotine of high specific activity, binding studies were
performed on rat brain membranes in the presence of a variety of nicotine analogues and …

The opiate receptor was purified from a Triton-solubilized preparation of rat neural membranes
by the use of affinity chromatography. The affinity gel was prepared by coupling 14-beta-…

Mecamylamine, an antagonist to nicotine, does not compete at the nicotinic recognition site,
but is believed to block the ion channel of the nicotinic receptor. The present study …

Reductive alkylation of neural membranes by N-ethyl malemide (NEM) converts muscarinic
acetylcholine receptors from a state of low to high affinity for receptor agonists. Interactions of …