The effects of 6-thioguanine on purine biosynthesis and cell viability have been examined
in H.Ep. 2 cells grown in culture. Toxicity is not reversed by aminoimidazolecar-boxamide, …

2-Chloro-9-(2-deoxy-2-fluoro-β-d-arabinofuranosyl)-adenine (Cl-F-ara-A) has activity against
the P388 tumor in mice on several different schedules. Biochemical studies with a chronic …

Activation of purine nucleoside analogs by Escherichia coli purine nucleoside phosphorylase
(PNP) is being evaluated as a suicide gene therapy strategy for the treatment of cancer. …

In an effort to understand biochemical features that are important to the selective antitumor
activity of 2-chloro-9-(2-deoxy-2-fluoro-β-d-arabinofuranosyl)adenine [Cl-F(↑)-dAdo], we …

Deazauridine inhibited growth of tumor cells in culture and in culture and in vivo; this agent
was significantly more effective against L1210/AraC than against the parent sensitive line. …

The effects of 2-amino-1,3,4-thiadiazole [aminothiadiazole (NSC 4728)] on purine and
pyrimidine ribonucleotide pools of L1210 ascites cells in vivo are presented and discussed as …

The synthesis and isolation of two derivatives of 2-amino-1,3,4-thiadiazole(aminothiadiazole)
are described. The derivatives are a nicotinamide adenine dinucleotide (NAD) analog …

Because of the excellent in vivo activity of 4′-thio-β-d-arabinofuranosylcytosine (T-araC)
against a variety of human solid tumors, we have studied its metabolism in CEM cells to …

Dichloroallyl lawsone [2-hydroxy-3-(3,3-dichloroallyl)-1,4-naphthoquinone, NSC 126771] is
of interest as an antitumor agent. Like certain other naphthoquinones, it is known to be a …

Neplanocin A and aristeromycin are carbocyclic adenosine analogs that differ only in that
neplanocin A contains a double bond in the carbocyclic ring, whereas this ring in aristeromycin …