The Na(+)-Ca2+ exchanger is an important regulator of cellular Ca2+ levels, and one
isoform of this transporter, NCX1, has been cloned previously (Nicoll, DA, Longoni, S., and …

The sarcolemmal Na(+)-Ca2+ exchanger is regulated by intracellular Ca2+ at a high affinity
Ca2+ binding site separate from the Ca2+ transport site. Previous data have suggested that …

Background Ex vivo heart perfusion (EVHP) provides the opportunity to resuscitate unused
donor organs and facilitates assessments of myocardial function that are required to …

We have examined the role of conserved regions and acidic or basic residues located in the
putative transmembrane segments of the cardiac sarcolemmal Na + -Ca 2+ exchanger by …

Ion transport and regulation of Na + –Ca 2+ exchange were examined for two alternatively
spliced isoforms of the canine cardiac Na + –Ca 2+ exchanger, NCX1.1, to assess the role(s) …

The Na + /Ca 2+ exchanger plays a prominent role in regulating intracellular Ca 2+ levels in
cardiac myocytes and can serve as both a Ca 2+ influx and efflux pathway. A novel inhibitor, …

… A preliminary report of this work has appeared in abstract form (Hryshko, LV, DA Nicoll, S. …
Larry V. Hryshko's present address is Division of Cardiovascular Sciences, St. Boniface …

Objective: Dietary intake of ω-3 polyunsaturated fatty acids (PUFA) like α-linolenic acid (ALA)
is antiarrhythmic and cardioprotective. PUFA may also be beneficial in hypertension. …

Background Normothermic ex vivo heart perfusion (EVHP) has been shown to improve the
preservation of hearts donated after circulatory arrest and to facilitate clinical successful …

Various procedures such as angioplasty, thrombolytic therapy, coronary bypass surgery,
and cardiac transplantation are invariably associated with ischemia–reperfusion (I/R) injury. …