The dopamine D 4 receptor (D 4 R) is predominantly expressed in the frontal cortex (FC), a
brain region that receives dense input from midbrain dopamine (DA) neurons and is …

Rationale Morphine relieves pain, in part, by acting on neurons within the periaqueductal
gray (PAG). Given that the PAG contains a subpopulation of dopamine neurons, dopamine …

Levodopa dose and severity of Parkinson's disease (PD) are recognized risk factors for
levodopa-induced dyskinesia (LID) in humans. The purpose of the present study was to evaluate …

Novel psychoactive substances, including synthetic substituted tryptamines, represent a
potential public health threat. Additionally, some substituted tryptamines are being studied …

Here, we map a quantitative trait locus (QTL) with a large effect on predisposition to barbiturate
(pentobarbital) withdrawal to a 0.44 Mb interval of mouse chromosome 1 syntenic with …

11 CO 2 is one of the major metabolites of many [11 C]-labeled radiopharmaceuticals, including
glucose, thymidine, acetate, amino acids, and fatty acids. Our data contradict the notion …

Chimeric D 1 /D 2 receptors were constructed to identify structural determinants of drug affinity
and efficacy. We previously reported that chimeras that had D 1 receptor transmembrane …

Functional interactions between adenosine A 2A and dopamine D 2 receptors have been
demonstrated both at the D 2 agonist-binding and second messenger levels. The present …

Background: The DBA/2J (D2) and C57BL/6J (B6) mouse strains are the most widely studied
genetic models of severe and mild acute alcohol withdrawal, respectively. Previous studies …

The aim of this study was to use pharmacological inhibition of protein kinase A and mutation
of potential protein kinase A phosphorylation sites to determine the role of protein kinase A-…