Three closely related forms of glycogen synthase kinase 3 (GSK-3α, GSK-3β and GSK-3β2)
have a major role in Wnt and Hedgehog signaling pathways and regulate the cell-division …

Cyclin-dependent kinases (CDKs) regulate the cell division cycle, apoptosis, transcription
and differentiation in addition to functions in the nervous system. Deregulation of CDKs in …

This article reviews the steps that have led us from very fundamental research on the cell
division cycle, investigated with the starfish oocyte model, to the identification of drugs now …

Human and mouse embryonic stem cells (HESCs and MESCs, respectively) self-renew
indefinitely while maintaining the ability to generate all three germ-layer derivatives. Despite the …

Cyclin‐dependent kinases (cdk) play an essential role in the intracellular control of the cell
division cycle (cdc). These kinases and their regulators are frequently deregulated in human …

Selective protein kinase inhibitors were developed on the basis of the unexpected binding
mode of 2,6,9-trisubstituted purines to the adenosine triphosphate–binding site of the human …

Indirubin is the active ingredient of Danggui Longhui Wan, a mixture of plants that is used in
traditional Chinese medicine to treat chronic diseases. Here we identify indirubin and its …

Gastropod mollusks have been used for over 2500 years to produce the "Tyrian purple" dye
made famous by the Phoenicians. This dye is constituted of mixed bromine-substituted …

Cyclin‐dependent kinases (cdk) control the cell division cycle (cdc). These kinases and
their regulators are frequently deregulated in human tumours. A potent inhibitor of cdks, …

The bis-indole indirubin is an active ingredient of Danggui Longhui Wan, a traditional
Chinese medicine recipe used in the treatment of chronic diseases such as leukemias. The …