Fibroblast growth factor (FGF) and FGF receptor-mediated autocrine signaling in non-small-cell lung cancer cells
…, P Hercule, WR Helton, JE Smith, LA McDermott… - Molecular …, 2009 - ASPET
Despite widespread expression of epidermal growth factor (EGF) receptors (EGFRs) and
EGF family ligands in non-small-cell lung cancer (NSCLC), EGFR-specific tyrosine kinase …
EGF family ligands in non-small-cell lung cancer (NSCLC), EGFR-specific tyrosine kinase …
[HTML][HTML] Novel combination of mitochondrial division inhibitor 1 (mdivi-1) and platinum agents produces synergistic pro-apoptotic effect in drug resistant tumor cells
W Qian, J Wang, V Roginskaya, LA McDermott… - Oncotarget, 2014 - ncbi.nlm.nih.gov
Overcoming platinum drug resistance represents a major clinical challenge in cancer
treatment. We discovered a novel drug combination using cisplatin and a class of …
treatment. We discovered a novel drug combination using cisplatin and a class of …
[HTML][HTML] Characterization of the interactions of potent allosteric inhibitors with glutaminase C, a key enzyme in cancer cell glutamine metabolism
Q Huang, C Stalnecker, C Zhang, LA McDermott… - Journal of Biological …, 2018 - ASBMB
Altered glycolytic flux in cancer cells (the "Warburg effect") causes their proliferation to rely
upon elevated glutamine metabolism ("glutamine addiction"). This requirement is met by the …
upon elevated glutamine metabolism ("glutamine addiction"). This requirement is met by the …
Design and evaluation of novel glutaminase inhibitors
LA McDermott, P Iyer, L Vernetti, S Rimer, J Sun… - Bioorganic & medicinal …, 2016 - Elsevier
… Author links open overlay panel Lee A. McDermott a b , Prema Iyer a b , Larry Vernetti b ,
Shawn Rimer a , Jingran Sun a , Melissa Boby a , Tianyi Yang a , Michael Fioravanti a , Jason O…
Shawn Rimer a , Jingran Sun a , Melissa Boby a , Tianyi Yang a , Michael Fioravanti a , Jason O…
[HTML][HTML] New insights into the molecular mechanisms of glutaminase C inhibitors in cancer cells using serial room temperature crystallography
…, DM Szebenyi, E Arenholz, LA McDermott… - Journal of Biological …, 2022 - ASBMB
Cancer cells frequently exhibit uncoupling of the glycolytic pathway from the TCA cycle (ie,
the "Warburg effect") and as a result, often become dependent on their ability to increase …
the "Warburg effect") and as a result, often become dependent on their ability to increase …
Screening and in vitro testing of antifolate inhibitors of human cytosolic serine hydroxymethyltransferase
…, G Montini, M Marani, A Paone, LA McDermott… - …, 2015 - Wiley Online Library
Metabolic reprogramming of tumor cells toward serine catabolism is now recognized as a
hallmark of cancer. Serine hydroxymethyltransferase (SHMT), the enzyme providing one‐…
hallmark of cancer. Serine hydroxymethyltransferase (SHMT), the enzyme providing one‐…
Pharmacological optimization for successful traumatic brain injury drug development
SM Poloyac, RJ Bertz, LA McDermott… - Journal of …, 2020 - liebertpub.com
The purpose of this review is to highlight the pharmacological barrier to drug development
for traumatic brain injury (TBI) and to discuss best practice strategies to overcome such …
for traumatic brain injury (TBI) and to discuss best practice strategies to overcome such …
Development of high-content assays for kidney progenitor cell expansion in transgenic zebrafish
…, ND Goldberg, LA McDermott… - Journal of …, 2013 - journals.sagepub.com
Reactivation of genes normally expressed during organogenesis is a characteristic of
kidney regeneration. Enhancing this reactivation could potentially be a therapeutic target to …
kidney regeneration. Enhancing this reactivation could potentially be a therapeutic target to …
[HTML][HTML] Characterization of allosteric modulators that disrupt androgen receptor co-activator protein-protein interactions to alter transactivation–Drug leads for …
AT Fancher, Y Hua, DA Close, W Xu, LA McDermott… - SLAS Discovery, 2023 - Elsevier
Three series of compounds were prioritized from a high content screening campaign that
identified molecules that blocked dihydrotestosterone (DHT) induced formation of Androgen …
identified molecules that blocked dihydrotestosterone (DHT) induced formation of Androgen …
RO4383596, an orally active KDR, FGFR, and PDGFR inhibitor: synthesis and biological evaluation
LA McDermott, M Simcox, B Higgins, T Nevins… - Bioorganic & medicinal …, 2005 - Elsevier
(±)-1-(anti-3-Hydroxy-cyclopentyl)-3-(4-methoxy-phenyl)-7-phenylamino-3,4-dihydro-1H-pyrimido[4,5-d]pyrimidin-2-one
(RO4383596) is a potent and selective inhibitor of the pro-…
(RO4383596) is a potent and selective inhibitor of the pro-…