Previous functional imaging studies have demonstrated a number of discrete brain structures
that increase activity with noxious stimulation. Of the commonly identified central structures, …

γ-Aminobutyric acid type A receptors (GABA A -Rs) mediate the bulk of rapid inhibitory synaptic
transmission in the central nervous system. The β3 subunit is an essential component of …

γ-Aminobutyric acid (GABA) type A receptors mediate fast inhibitory synaptic transmission
and have been implicated in responses to sedative/hypnotic agents (including neuroactive …

We have redetermined the anaesthetic potencies (EC50S) for a series of primary alkanols, to
resolve uncertainties about the molecular dimensions of the anaesthetic site resulting from …

Rationale: Previous fluorescence studies employing 1,6-diphenyl-1,3,5-hexatriene (DPH)
have revealed an increase in the fluidity of platelet membranes from individuals with Alzheimer…

Recent positron emission tomography (PET) studies have demonstrated areas of pain
processing in the human brain. Given the inhibitory effects of opioids on neuronal activity, we …

Background The mammalian gamma-aminobutyric acid type A (GABA(A)) receptor, a likely
target of anesthetic action, exhibits remarkable subunit heterogeneity. In vitro expression …

Gene-targeting technology is creating an explosion in the number of animals available with
single gene mutations that affect the function of the central nervous system. Most gene-…

The α6 subunit of the γ-aminobutyric acid type A receptor (GABA A -R) has been implicated
in mediating the intoxicating effects of ethanol and the motor ataxic effects of general …

Positron emission tomography (PET) is a noninvasive imaging technique that can be used
to observe drug actions on human brain in vivo. We used 15 O-water PET scanning in six …