Curcumin and its nano-formulation: the kinetics of tissue distribution and blood–brain barrier penetration

YM Tsai, CF Chien, LC Lin, TH Tsai - International journal of pharmaceutics, 2011 - Elsevier
Curcumin has considerable neuro-protective and anti-cancer properties but is rapidly
eliminated from the body. By optimizing the HPLC method for analysis of curcumin, this study …

Drug–drug interactions of silymarin on the perspective of pharmacokinetics

JW Wu, LC Lin, TH Tsai - Journal of ethnopharmacology, 2009 - Elsevier
Silymarin, which is extracted from the milk thistle (Silybum marianum), has been used for
centuries for treating hepatic disorders and its hepatoprotective effects have been known for …

Analysis of silibinin in rat plasma and bile for hepatobiliary excretion and oral bioavailability application

JW Wu, LC Lin, SC Hung, CW Chi, TH Tsai - Journal of pharmaceutical and …, 2007 - Elsevier
Silibinin is an herbal ingredient isolated from milk thistle. The aim of this study was to
develop a simple liquid chromatographic system to assay silibinin in plasma and bile for …

Isolation of Luteolin and Luteolin-7-O-glucoside from Dendranthema morifolium Ramat Tzvel and Their Pharmacokinetics in Rats

LC Lin, YF Pai, TH Tsai - Journal of agricultural and food chemistry, 2015 - ACS Publications
Luteolin and luteolin-7-O-glucoside were isolated from the ethanolic extract of Dendranthema
morifolium Ramat Tzvel. The structures of these analytes were identified by nuclear …

Cytotoxic Biflavonoids from Selaginella delicatula

LC Lin, YC Kuo, CJ Chou - Journal of Natural Products, 2000 - ACS Publications
Lie-Chwen LinLie-Chwen Lin - National Research Institute of Chinese Medicine, Pettou,
Taipei 112… Li, Shaoguang Li, Peiying Shi, Xinhua Lin. Analysis of the Total Biflavonoids Extract …

Optimised nano-formulation on the bioavailability of hydrophobic polyphenol, curcumin, in freely-moving rats

YM Tsai, WC Jan, CF Chien, WC Lee, LC Lin, TH Tsai - Food chemistry, 2011 - Elsevier
This study has optimised the poly lactic-co-glycolic acid (PLGA) nano-formulation of
curcumin to prolong its retention time in the body and improve bioavailability. High-pressure …

Cytotoxic naphthoquinones and plumbagic acid glucosides from Plumbago zeylanica

LC Lin, LL Yang, CJ Chou - Phytochemistry, 2003 - Elsevier
Two plumbagic acid glucosides, 3′-O-β-glucopyranosyl plumbagic acid and 3′-O-β-glucopyranosyl
plumbagic acid methylester along with five naphthoquinones (plumbagin, …

Samarangenin B from Limonium sinense Suppresses Herpes Simplex Virus Type 1 Replication in Vero Cells by Regulation of Viral Macromolecular Synthesis

YC Kuo, LC Lin, WJ Tsai, CJ Chou… - Antimicrobial agents …, 2002 - Am Soc Microbiol
Inhibitory effects of ethanolic extracts from 10 Chinese herbs on herpes simplex virus type 1
(HSV-1) replication were investigated. By a bioassay-guided fractionation procedure, …

Immunomodulatory functions of extracts from the Chinese medicinal fungus Cordyceps cicadae

SC Weng, CJ Chou, LC Lin, WJ Tsai, YC Kuo - Journal of …, 2002 - Elsevier
The effects of Cordyceps cicadae extracted fractions on human mononuclear cells (HMNC)
proliferation were determined by tritiated thymidine uptake. The results indicated that …

Limonium sinense and gallic acid suppress hepatitis C virus infection by blocking early viral entry

…, LC Lin, CL Li, CD Richardson, CC Lin, LT Lin - Antiviral research, 2015 - Elsevier
A preventive vaccine against hepatitis C virus (HCV) infection remains unavailable and newly
developed drugs against viral replication are complicated by potential drug-resistance and …