Altered expression of hypothalamic neuropeptide mRNAs in food-restricted and food-deprived rats

LS Brady, MA Smith, PW Gold, M Herkenham - Neuroendocrinology, 1990 - karger.com
Hypothalamic neuropeptides play a role in appetite and weight regulation. Food restriction for
2 weeks and food deprivation for 4 days were used as models to characterize the effects of …

Enhancement of dynorphin gene expression in spinal cord following experimental inflammation: stimulus specificity, behavioral parameters and opioid receptor …

MJ Iadarola, LS Brady, G Draisci, R Dubner - Pain, 1988 - Elsevier
The stimulus specificity for enhancement of dynorphin gene expression in rat spinal cord was
studied by combined measurements of the peptide dynorphin A 1–8 and preprodynorphin …

NIH molecular libraries initiative

CP Austin, LS Brady, TR Insel, FS Collins - Science, 2004 - science.org
Policy Forum www. sciencemag. org SCIENCE VOL 306 12 NOVEMBER 2004 1139 ology
and disease. The first of the MLSCN screening centers (the NIH Chemical Genomics Center) …

The antidepressants fluoxetine, idazoxan and phenelzine alter corticotropin-releasing hormone and tyrosine hydroxylase mRNA levels in rat brain: therapeutic …

LS Brady, PW Gold, M Herkenham, AB Lynn… - Brain research, 1992 - Elsevier
Various classes of antidepressant drugs with distinct pharmacologic actions are
differentially effective in the treatment of classic melancholic depression — characterized by …

[HTML][HTML] Advancing biological understanding and therapeutics discovery with small-molecule probes

…, MR Wood, SR Stauffer, KA Emmitte, LS Brady… - Cell, 2015 - cell.com
Small-molecule probes can illuminate biological processes and aid in the assessment of
emerging therapeutic targets by perturbing biological systems in a manner distinct from other …

Unilateral LTP triggers bilateral increases in hippocampal neurotrophin and trk receptor mRNA expression in behaving rats: Evidence for interhemispheric …

…, JM Sarvey, M Herkenham, LS Brady - Journal of …, 1996 - Wiley Online Library
Induction of long‐term potentiation (LTP) in the dentate gyrus of awake rats triggered a
rapid (2 hour) elevation in tyrosine kinase receptor (trkB and trkC) gene expression and a …

Repeated immobilization stress alters tyrosine hydroxylase, corticotropin‐releasing hormone and corticosteroid receptor messenger ribonucleic acid levels in rat brain

E Mamalaki, R Kvetnansky, LS Brady… - Journal of …, 1992 - Wiley Online Library
In situ hybridization histochemistry was used to localize and quantify the effects of acute and
repeated immobilization stress on mRNA levels of tyrosine hydroxylase (TH) in …

Systemic interleukin-1 induces early and late patterns of c-fos mRNA expression in brain

LS Brady, AB Lynn, M Herkenham… - Journal of …, 1994 - Soc Neuroscience
This study was designed to examine the mechanisms by which systemic interleukin-1
affects neuroendocrine systems in the brain. Intraperitoneal injections of interleukin-1 beta (1.25 …

[PDF][PDF] Medicines for the mind: policy-based “pull” incentives for creating breakthrough CNS drugs

…, R Armitage, LS Brady, T Coetzee, W Fisher, S Hyman… - Neuron, 2014 - cell.com
Several large pharmaceutical companies have selectively downsized their neuroscience
research divisions, reflecting a growing view that developing drugs to treat brain diseases is …

Optimization of cRNA probe in situ hybridization methodology for localization of glucocorticoid receptor mRNA in rat brain: a detailed protocol.

HJ Whitfield Jr, LS Brady, MA Smith… - Cellular and …, 1990 - europepmc.org
1. We have described a general ribonucleotide probe in situ hybridization methodology for
localization of mRNA in frozen, unfixed tissue sections of brain. 2. The most important steps in …