An epididymis-specific β-defensin is important for the initiation of sperm maturation

CX Zhou, YL Zhang, L Xiao, M Zheng, KM Leung… - Nature cell …, 2004 - nature.com
Although the role of the epididymis, a male accessory sex organ, in sperm maturation has
been established for nearly four decades 1 , the maturation process itself has not been linked …

Hedgehog proteins activate pro-angiogenic responses in endothelial cells through non-canonical signaling pathways

P Chinchilla, L Xiao, MG Kazanietz, NA Riobo - Cell cycle, 2010 - Taylor & Francis
The Hedgehog (Hh) pathway orchestrates developmental and homeostatic angiogenesis. The
three Hh isoforms- Sonic Hedgehog (Shh), Indian Hedgehog (Ihh) and Desert Hedgehog (…

Molecular mechanisms of protein kinase C-induced apoptosis in prostate cancer cells

AM Gonzalez-Guerrico, J Meshki, L Xiao… - BMB …, 2005 - koreascience.kr
Protein kinase C (PKC) isozymes, a family of serine-threonine kinases, are important
regulators of cell proliferation and malignant transformation. Phorbol esters, the prototype PKC …

Bryostatin 1 inhibits phorbol ester-induced apoptosis in prostate cancer cells by differentially modulating protein kinase C (PKC) δ translocation and preventing PKCδ …

VA von Burstin, L Xiao, MG Kazanietz - Molecular pharmacology, 2010 - ASPET
Bryostatin 1, a macrocyclic lactone that has been widely characterized as an ultrapotent
protein kinase C (PKC) activator, displays marked pharmacological differences with the typical …

[HTML][HTML] ROCK mediates phorbol ester-induced apoptosis in prostate cancer cells via p21Cip1 up-regulation and JNK

L Xiao, M Eto, MG Kazanietz - Journal of biological chemistry, 2009 - ASBMB
It is established that androgen-dependent prostate cancer cells undergo apoptosis upon
treatment with phorbol esters and related analogs, an effect primarily mediated by PKCδ. …

[HTML][HTML] p23/Tmp21 associates with protein kinase Cδ (PKCδ) and modulates its apoptotic function

HB Wang, L Xiao, MG Kazanietz - Journal of Biological Chemistry, 2011 - ASBMB
There is emerging evidence that C1 domains, motifs originally identified in PKC isozymes
and responsible for binding of phorbol esters and diacylglycerol, interact with the Golgi/…

[HTML][HTML] Parameter tuning of PID controller for beer filling machine liquid level control based on improved genetic algorithm

L Xiao - Computational Intelligence and Neuroscience, 2021 - hindawi.com
Parameter tuning of PID controller for liquid level control of beer filling machine was studied
in this paper, which can meet the demand of accurate controlling in beer production and …

[HTML][HTML] Intramedullary megakaryocytes internalize released platelet factor 4 and store it in alpha granules

MP Lambert, R Meng, L Xiao, DC Harper… - Journal of Thrombosis …, 2015 - Elsevier
Background Megakaryocytes express and store platelet factor 4 (PF4) in alpha granules. In
vivo, PF4 is a clinically relevant, negative regulator of megakaryopoiesis and hematopoietic …

PKC‐mediated secretion of death factors in LNCaP prostate cancer cells is regulated by androgens

L Xiao, A Gonzalez‐Guerrico… - … in cooperation with the …, 2009 - Wiley Online Library
Activation of PKCδ in androgen‐dependent LNCaP prostate cancer cells leads to apoptosis
via the activation of p38 MAPK and JNK cascades. We have recently shown that treatment of …

Phorbol Ester–Induced Apoptosis and Senescence in Cancer Cell Models

L Xiao, MC Caino, VA von Burstin, JL Oliva… - Methods in …, 2008 - Elsevier
Protein kinase C (PKC) isozymes catalyze the phosphorylation of substrates that play key
roles in the control in proliferation, differentiation, and survival. Treatment of cells with phorbol …