The histone deacetylase inhibitor MS-275 interacts synergistically with fludarabine to induce apoptosis in human leukemia cells
SC Maggio, RR Rosato, LB Kramer, Y Dai, M Rahmani… - Cancer research, 2004 - AACR
Interactions between the novel benzamide histone deacetylase (HDAC) inhibitor MS-275
and fludarabine were examined in lymphoid and myeloid human leukemia cells in relation to …
and fludarabine were examined in lymphoid and myeloid human leukemia cells in relation to …
Interruption of the Ras/MEK/ERK signaling cascade enhances Chk1 inhibitor–induced DNA damage in vitro and in vivo in human multiple myeloma cells
…, XY Pei, JA Almenara, LB Kramer… - Blood, The Journal …, 2008 - ashpublications.org
The role of the Ras/MEK/ERK pathway was examined in relation to DNA damage in human
multiple myeloma (MM) cells exposed to Chk1 inhibitors in vitro and in vivo. Exposure of …
multiple myeloma (MM) cells exposed to Chk1 inhibitors in vitro and in vivo. Exposure of …
Interactions between bortezomib and romidepsin and belinostat in chronic lymphocytic leukemia cells
Y Dai, S Chen, LB Kramer, VL Funk, P Dent… - Clinical cancer …, 2008 - AACR
Purpose: The goal of this study was to characterize interactions between the proteasome
inhibitor bortezomib and the histone deacetylase (HDAC) inhibitors (HDACI) romidepsin or …
inhibitor bortezomib and the histone deacetylase (HDAC) inhibitors (HDACI) romidepsin or …
[HTML][HTML] Induction of apoptosis and potentiation of ceramide-mediated cytotoxicity by sphingoid bases in human myeloid leukemia cells
…, FA Fornari, RS Traylor, HA Martin, LB Kramer… - Journal of Biological …, 1996 - ASBMB
Prior studies demonstrated that ceramide promotes apoptotic cell death in the human myeloid
leukemia cell lines HL-60 and U937 (Jarvis, WD, Kolesnick, RN, Fornari, FA, Jr., Traylor, …
leukemia cell lines HL-60 and U937 (Jarvis, WD, Kolesnick, RN, Fornari, FA, Jr., Traylor, …
Bortezomib interacts synergistically with belinostat in human acute myeloid leukaemia and acute lymphoblastic leukaemia cells in association with perturbations in NF …
…, S Chen, L Wang, XY Pei, LB Kramer… - British journal of …, 2011 - Wiley Online Library
Interactions between the histone deacetylase inhibitor belinostat and the proteasome inhibitor
bortezomib were investigated in acute myeloid leukaemia (AML) and acute lymphoblastic …
bortezomib were investigated in acute myeloid leukaemia (AML) and acute lymphoblastic …
CDK inhibitors upregulate BH3-only proteins to sensitize human myeloma cells to BH3 mimetic therapies
S Chen, Y Dai, XY Pei, J Myers, L Wang, LB Kramer… - Cancer research, 2012 - AACR
BH3 mimetic drugs induce cell death by antagonizing the activity of antiapoptotic Bcl-2
family proteins. Cyclin-dependent kinase (CDK) inhibitors that function as transcriptional …
family proteins. Cyclin-dependent kinase (CDK) inhibitors that function as transcriptional …
Cytokinetically quiescent (G0/G1) human multiple myeloma cells are susceptible to simultaneous inhibition of Chk1 and MEK1/2
…, J Felthousen, JA Almenara, LB Kramer… - Blood, The Journal …, 2011 - ashpublications.org
Abstract Effects of Chk1 and MEK1/2 inhibition were investigated in cytokinetically quiescent
multiple myeloma (MM) and primary CD138 + cells. Coexposure to the Chk1 and MEK1/2 …
multiple myeloma (MM) and primary CD138 + cells. Coexposure to the Chk1 and MEK1/2 …
Cotreatment with suberanoylanilide hydroxamic acid and 17-allylamino 17-demethoxygeldanamycin synergistically induces apoptosis in Bcr-Abl+ Cells sensitive and …
M Rahmani, E Reese, Y Dai, C Bauer, LB Kramer… - Molecular …, 2005 - ASPET
Interactions between the histone deacetylase (HDAC) inhibitors suberanoylanilide hydroxamic
acid (SAHA) and sodium butyrate (SB) and the heat shock protein (Hsp) 90 antagonist 17-…
acid (SAHA) and sodium butyrate (SB) and the heat shock protein (Hsp) 90 antagonist 17-…
[HTML][HTML] Circumvention of Mcl-1-dependent drug resistance by simultaneous Chk1 and MEK1/2 inhibition in human multiple myeloma cells
…, MW Sanderson, WW Bodie, LB Kramer… - PloS one, 2014 - journals.plos.org
The anti-apoptotic protein Mcl-1 plays a major role in multiple myeloma (MM) cell survival
as well as bortezomib- and microenvironmental forms of drug resistance in this disease. …
as well as bortezomib- and microenvironmental forms of drug resistance in this disease. …
Agents that down-regulate or inhibit protein kinase C circumvent resistance to 1-β-D-arabinofuranosylcytosine-induced apoptosis in human leukemia cells that …
…, AJ Freemerman, WD Jarvis, LB Kramer… - Molecular …, 1997 - ASPET
The effects of the non-tumor-promoting protein kinase C (PKC) activator bryostatin 1 and the
PKC inhibitors staurosporine and UCN-01 were examined with respect to modulation of 1-[β…
PKC inhibitors staurosporine and UCN-01 were examined with respect to modulation of 1-[β…