Impaired type II glucocorticoid-receptor function in mice bearing antisense RNA transgene
MC Pepin, F Pothier, N Barden - Nature, 1992 - nature.com
GLUCOCORTICOIDS, in conjunction with their cognate receptors, exert negative-feedback
effects on the hypothalamus-pituitary-adrenal axis, suppressing adrenal steroid secretions. …
effects on the hypothalamus-pituitary-adrenal axis, suppressing adrenal steroid secretions. …
[HTML][HTML] Functional roles for the cytoplasmic domain of the type III transforming growth factor β receptor in regulating transforming growth factor β signaling
GC Blobe, WP Schiemann, MC Pepin… - Journal of Biological …, 2001 - ASBMB
Transforming growth factor β (TGF-β) signals through three high affinity cell surface receptors,
TGF-β type I, type II, and type III receptors. The type III receptor, also known as betaglycan, …
TGF-β type I, type II, and type III receptors. The type III receptor, also known as betaglycan, …
Antidepressants regulate glucocorticoid receptor messenger RNA concentrations in primary neuronal cultures
MC Pepin, S Beaulieu, N Barden - Molecular Brain Research, 1989 - Elsevier
Increased cortisol secretion, caused by hyperactivity of the brain-pituitary-adrenal axis, and
non-suppression of cortisol secretion following dexamethasone administration are two …
non-suppression of cortisol secretion following dexamethasone administration are two …
Antiangiogenic and antimetastatic properties of Neovastat (AE-941), an orally active extract derived from cartilage tissue
…, SA Mousa, V Dimitriadou, MC Pepin… - Clinical & experimental …, 2002 - Springer
A novel naturally occurring antiangiogenic agent isolated from cartilage, referred to as
Neovastat (Æ-941), was examined for its efficacy against tumor neovascularization and …
Neovastat (Æ-941), was examined for its efficacy against tumor neovascularization and …
Increased glucocorticoid receptor gene promoter activity after antidepressant treatment.
MC Pepin, MV Govindan, N Barden - Molecular pharmacology, 1992 - ASPET
We have tested the hypothesis that antidepressants affect the expression of the glucocorticoid
receptor gene, by looking at glucocorticoid receptor gene promoter activity, glucocorticoid …
receptor gene, by looking at glucocorticoid receptor gene promoter activity, glucocorticoid …
The antiangiogenic agent neovastat (AE-941) inhibits vascular endothelial growth factor-mediated biological effects
…, F Baffert, E Beaulieu, V Dimitriadou, MC Pépin… - Clinical cancer …, 2002 - AACR
Purpose: Vascular endothelial growth factor (VEGF) is a potent regulator of angiogenesis,
which exerts direct effects on vascular endothelial cells, including endothelial cell proliferation …
which exerts direct effects on vascular endothelial cells, including endothelial cell proliferation …
[PDF][PDF] Antidepressant drug action in a transgenic mouse model of the endocrine changes seen in depression.
MC Pepin, F Pothier, N Barden - Molecular pharmacology, 1992 - Citeseer
We have created transgenic mouse lines with impaired gluco-corticoid receptor function by
expression of a type II glucocorti-coid receptor antisense RNA in brain tissues. These …
expression of a type II glucocorti-coid receptor antisense RNA in brain tissues. These …
Energy balance and lipid metabolism in transgenic mice bearing an antisense GCR gene construct
…, Y Deshaies, MC Pepin… - American Journal …, 1993 - journals.physiology.org
Energy balance and lipid metabolism were investigated in transgenic mice bearing an antisense
glucocorticoid receptor (GCR) gene construct that impairs the normal expression of the …
glucocorticoid receptor (GCR) gene construct that impairs the normal expression of the …
Mapping of the ligand binding domain of the transforming growth factor beta receptor type III by deletion mutagenesis.
MC Pepin, M Beauchemin… - Proceedings of the …, 1994 - National Acad Sciences
Transforming growth factor beta (TGF-beta) receptor type III is a membrane-anchored
proteoglycan that binds TGF-beta via the core protein. We have determined, by deletion …
proteoglycan that binds TGF-beta via the core protein. We have determined, by deletion …
[HTML][HTML] High power normally-OFF GaN/AlGaN HEMT with regrown p type GaN
In this paper is presented a Normally-OFF GaN HEMT (High Electron Mobility Transistor)
device using p-doped GaN barrier layer regrown by CBE (Chemical Beam Epitaxy). The impact …
device using p-doped GaN barrier layer regrown by CBE (Chemical Beam Epitaxy). The impact …