… The budding yeast functional MK homologues Rck1 and Rck2 suppress cell-cycle-checkpoint
mutations when expressed in fission yeast by prolonging the G2/M transition 29 . But can …

Inflammation is an evolutionarily conserved host reaction that is initiated in response to
trauma, tissue damage and infection. It leads to changes in tissue homeostasis and blood flow, …

… Ronkina & M. Gaestel, unpublished observations) could rescue Hsp25 phosphorylation or
the p38 protein level in MK2 KO or MK2/3 DKO cells, indicating that, in spite of its similarity to …

Small heat shock proteins (sHsp) with a molecular mass of 15-30 kDa are ubiquitous and
conserved. Up to now their function has remained enigmatic. Increased expression under heat …

Stabilization of mRNAs contributes to the strong and rapid induction of genes in the inflammatory
response. The signaling mechanisms involved were investigated using a tetracycline‐…

… mmα-glycerophosphate, pH 7.4, 0.1 mm EDTA, and 4 mm magnesium acetate at 30 C for 3
h. Before and after the incubation aliquots of 10 μl were taken and proteins were precipitated …

Small heat shock proteins (sHsps) are a conserved and ubiquitous protein family. Their
ability to convey thermoresistance suggests their participation in protecting the native …

… The two bands correspond to the 46K (M r 46,000) and 54K isoforms of MK2 (ref. 22). The
… For ‘in gel’ kinase assays, 10 7 cells were treated with UV (254 nm, 150 J m -2 ) or arsenite (…

MAP kinase‐activated protein kinase‐2 (MAPKAP kinase‐2) phosphorylates the serine
residues in murine heat shock protein 25 (hsp25) and human heat shock protein 27 (hsp27) …

Macrophages and microglia can be polarized along a continuum toward a detrimental (M1)
or a beneficial (M2) state in the injured CNS. Although phagocytosis of myelin in vitro …