Clonidine binds to imidazole binding sites as well as α2-adrenoceptors in the ventrolateral medulla

P Ernsberger, MP Meeley, JJ Mann, DJ Reis - European journal of …, 1987 - Elsevier
Binding sites labeled by [ 3 H]p-aminoclonidine ([ 3 H]PAC) were characterized in bovine
brain membranes prepared from the ventrolateral medulla, the probable site of the …

Intrinsic neurons in the amygdaloid field projected to by the medial geniculate body mediate emotional responses conditioned to acoustic stimuli

J Iwata, JE LeDoux, MP Meeley, S Arneric, DJ Reis - Brain research, 1986 - Elsevier
In previous experiments we implicated projections from the medial geniculate body (MG) to
a subcortical field, involving portions of the posterior caudate-putamen and amygdala, in the …

Intrinsic γ-aminobutyric acid neurons in the nucleus of the solitary tract and the rostral ventrolateral medulla of the rat: an immunocytochemical and biochemical study

MP Meeley, DA Ruggiero, T Ishitsuka, DJ Reis - Neuroscience letters, 1985 - Elsevier
Sympathoexcitatory neurons in the C1 adrenergic area of the rostral ventrolateral medulla (RVL)
are tonically inhibited by γ-aminobutyric acid (GABA). To identify the source of this …

Content and in vitro release of endogenous amino acids in the area of the nucleus of the solitary tract of the rat

MP Meeley, MD Underwood… - Journal of …, 1989 - Wiley Online Library
We sought to identify amino acid neurotransmitter candidates within the nucleus of the solitary
tract in rats. Twenty endogenous amino acids were quantified by reverse‐phase HPLC …

An endogenous clonidine-displacing substance from bovine brain: receptor binding and hypotensive actions in the ventrolateral medulla

MP Meeley, PR Ernsberger, AR Granata, DJ Reis - Life sciences, 1986 - Elsevier
A substance has been isolated from bovine brain which displaces 3 H-clonidine binding to
rat brain membranes (clonidine-displacing substance; CDS). To determine whether CDS is …

Isolation and characterization of imidazoline receptor protein from bovine adrenal chromaffin cells.

H Wang, S Regunathan, MP Meeley, DJ Reis - Molecular pharmacology, 1992 - ASPET
We sought to isolate and partially purify proteins corresponding to the binding element of the
imidazoline receptor (IR) from adrenal chromaffin cell membranes. These cells express IRs …

An endogenous substance with clonidine-like properties: selective binding to imidazole sites in the ventrolateral medulla

P Ernsberger, MP Meeley, DJ Reis - Brain research, 1988 - Elsevier
We sought to characterize the interactions of an endogenous clonidine-displacing substance
(CDS) with the specific receptor sites to which clonidine and its analogs bind: (a) the non-…

Imidazole receptors and clonidine-displacing substance in relationship to control of blood pressure, neuroprotection, and adrenomedullary secretion

…, S Regunathan, MP Meeley - American journal of …, 1992 - academic.oup.com
… Reis DJ, Ernsberger P, Meeley MP: Imidazole receptors and their endogenous ligand in
the rostral ventrolateral medulla: relationship to the action of clonidine on arterial pressure, in …

Selective alkylation of cycloheptaamylose

RJ Bergeron, MP Meeley, Y Machida - Bioorganic Chemistry, 1976 - Elsevier
The verification of a number of assumptions made about cycloamylose structure, substrate
binding and catalysis is dependent on the ability to 3-O-alkylate selectively these …

Newly identified GABAergic neurons in regions of the ventrolateral medulla which regulate blood pressure

DA Ruggiero, MP Meeley, M Anwar, DJ Reis - Brain research, 1985 - Elsevier
Glutamic acid decarboxylase (GAD), the enzyme which synthesizes the inhibitory transmitter
gamma-aminobutyric acid (GABA), was localized immunocytochemically within cells and …