Defensive chemicals of the Spanisch dancer nudibranch Hexabranchus sanguineus and its egg ribbons: macrolides derived from a sponge diet

JR Pawlik, MR Kernan, TF Molinski, MK Harper… - Journal of Experimental …, 1988 - Elsevier
… standard spectrometric techniques (Keman & Faulkner, 1987; Kernan, 1988). The purified
macrolides, along with … KERNAN, MR, 1988. The chemistry of some marine sponges. Ph.…

SP-303, an antiviral oligomeric proanthocyanidin from the latex of Croton lechleri (Sangre de Drago).

R Ubillas, SD Jolad, RC Bruening, MR Kernan… - Phytomedicine, 1994 - Elsevier
SP-303, a large proanthocyanidin oligomer isolated from the latex of the plant species Croton
lechleri (Eupborbiaceae) has demonstrated broad activity against a variety of DNA and …

Antiviral Phenylpropanoid Glycosides from the Medicinal Plant Markhamia lutea

MR Kernan, A Amarquaye, JL Chen… - Journal of Natural …, 1998 - ACS Publications
Three new phenylpropanoid glycosides, named luteoside A (3), luteoside B (4), and
luteoside C (5), were isolated together with the known compounds verbascoside (1) and …

New Iridoids from the Medicinal Plant Barleria prionitis with Potent Activity against Respiratory Syncytial Virus

…, M Balick, W Nanakorn, MR Kernan - Journal of natural …, 1998 - ACS Publications
Two new iridoid glycosides (1 and 2), together with the known compounds barlerin (3) and
verbascoside (4), were isolated from Barleria prionitis. The new iridoid glycosides were …

Regioselective oxidation of 3-alkylfurans to 3-alkyl-4-hydroxybutenolides

MR Kernan, DJ Faulkner - The Journal of Organic Chemistry, 1988 - ACS Publications
3-Alkyl-4-hydroxybutenolides are synthesized in good tohigh yields by the oxidation of 3-alkylfurans
with singlet oxygen, generated from molecular oxygen with a polymer-bound rose …

Macrocyclic antifungal metabolites from the Spanish dancer nudibranch Hexabranchus sanguineus and sponges of the genus Halichondria

MR Kernan, TF Molinski… - The Journal of Organic …, 1988 - ACS Publications
A marine sponge Halichondria sp. contained halichondramide (4) as the major constituent
and dihydro-halichondramide (6), isohalichondramide (10), acid 11, imide 12, and ester 13 as …

Two New Lignans with Activity against Influenza Virus from the Medicinal Plant Rhinacanthus nasutus

MR Kernan, A Sendl, JL Chen, SD Jolad… - Journal of Natural …, 1997 - ACS Publications
Two new lignans, rhinacanthin E (1) and rhinacanthin F (2), were isolated from the aerial
parts of the plant Rhinacanthus nasutus. Their structures were established by detailed …

Manoalide: structure-activity studies and definition of the pharmacophore for phospholipase A2 inactivation.

…, MS De Carvalho, RS Jacobs, MR Kernan… - Molecular …, 1989 - ASPET
Manoalide is a potent antiinflammatory marine natural product and a direct inactivator of
venom phospholipase A2 (PLA2; EC 3.1.1.4). Manoalide has been shown to irreversibly inhibit …

Chemistry of sponges, VII. 11, 19-Dideoxyfistularin 3 and 11-hydroxyaerothionin, bromotyrosine derivatives from Pseudoceratina durissima

MR Kernan, RC Cambie… - Journal of Natural …, 1990 - ACS Publications
11, 19-Dideoxyfistularin 3 [3] and 11-hydroxyaerothionin [6], two new bromotyrosine-derived
metabolites, have been isolatedfrom the verongid sponge Pseudoceratina durissima, along …

Halichondramide, an antifungal macrolide from the sponge Halichondria sp.

MR Kernan, DJ Faulkner - Tetrahedron letters, 1987 - Elsevier
Abstract The structure of halichondramide (2), an antifungal macrolide from the Pacific
sponge Halichondria sp., was elucidated by interpretation of spectral data.