… Evans, RM, and Hakala, MT Role of recovery of thymidylate … Laskin, JD, and Hakala,
MT Assessment of growth-limiting … Hakala, MT Prevention of toxicity of amethopterin for S-180 …

The synthesis of (,-2-)-*. vethyl-, N'-bvnzyl-. X’-z/.-liexvl-, N'^/j-pont vi-. X ‘-phenyl-, X, l-2-t
liienyl-, and X*'i-2-(* 1 hoxyetIndadenosines was carried out by<| iiatemization of the N1 of …

The purpose of this study was to compare the pools of free FdUMP derived from 5-fluorouracil
(FUra) and of dUMP synthesized de novo in Hep-2 and S-180 cells, their relationship to …

The synthesis of N6-isoamyl-, N6-n-propyl-, N6-isopropyl-, and N6-allyIadenosine and N6-isoamyladenine
was carried out by a general method involving the condensation of 6-…

The purpose of this study was to assess the significance of thymidylate synthetase (dTMP
synthetase) inhibition in growth inhibition caused by 5-fluorouracil (FUra). Three fibroblastic …

… The value of cell water for 5-180 obtained here is similar to that previously found by Hakala
(13… Hakala, MT On the Role of Drug Penetration in Amethopterin Resist ance of the Sarcoma …

The present paper is a preliminary re-port on the finding that sarcoma-180 (S-180) cells grow
normally when the function of folic acid is prevented by amethopterin (Methotrexate), if the …

1. The measurement of the net rate of influx of amethopterin was based on the rate of formation
of the intracellular folic acid reductase-amethopterin complex. This rate was found to be …

… Hakala, MT Prevention of Toxicity of Amethoplcrin for Sarcoma 180 Cells in Tissue Cullure.
… Hakala, MT On Ihe Role of Drug Penelralion in Amethopterin Resistence of Sarcoma 180 …

The rate of net influx of amethopterin into sublines of Sarcoma-180 cells in vitro (4.6 · 10 −8
cm/sec at 36) was shown to be dependent on at least four processes: (a) slow influx, …