The 28 mammalian members of the super-family of transient receptor potential (TRP) channels
are cation channels, mostly permeable to both monovalent and divalent cations, and can …

TRP channels constitute a large superfamily of cation channel forming proteins, all related
to the gene product of the transient receptor potential (trp) locus in Drosophila. In mammals, …

Platinum-based anticancer drugs cause neurotoxicity. In particular, oxaliplatin produces
early-developing, painful, and cold-exacerbated paresthesias. However, the mechanism …

Topical application of nicotine, as used in nicotine replacement therapies, causes irritation
of the mucosa and skin. This reaction has been attributed to activation of nicotinic …

Mustard oil (MO) is a plant-derived irritant that has been extensively used in experimental
models to induce pain and inflammation [1, 2]. The noxious effects of MO are currently …

TRPA1 is a nonselective cation channel activated by a wide variety of noxious chemicals.
Intriguingly, several TRPA1 modulators induce a bimodal effect, activating the channel at …

Allyl isothiocyanate (AITC; aka, mustard oil) is a powerful irritant produced by Brassica plants
as a defensive trait against herbivores and confers pungency to mustard and wasabi. AITC …

Cystic fibrosis (CF) is caused by mutations in the gene for the cystic fibrosis transmembrane
conductance regulator (CFTR). With the discovery of Ivacaftor and Orkambi, it has been …

… Maarten Gees … Tomasz Jaworski, Ilse Dewachter, Benoit Lechat, Maarten Gees, Anna
Kremer, David Demedts, Peter Borghgraef, Herman Devijver & Fred Van Leuven … Maarten Gees …

The powerful plant-derived irritant allyl isothiocyanate (AITC, aka mustard oil) induces
hyperalgesia to heat in rodents and humans through mechanisms that are not yet fully understood…