Exercise promotes longevity and ameliorates type 2 diabetes mellitus and insulin resistance.
However, exercise also increases mitochondrial formation of presumably harmful reactive …

Increasing cellular glucose uptake is a fundamental concept in treatment of type 2 diabetes,
whereas nutritive calorie restriction increases life expectancy. We show here that increased …

Covering: 1934 to early 2002.The biochemistry of selenium-containing natural products,
including selenoproteins, is reviewed up to May 2002. Particular emphasis is placed on the …

The discovery of vitamin E will have its 100th anniversary in 2022, but we still have more
questions than answers regarding the biological functions and the essentiality of vitamin E for …

A recent human intervention trial showed that daily supplementation with selenized yeast (Se-yeast)
led to a decrease in the overall cancer morbidity and mortality by nearly 50%; past …

Selenium-enriched plants, such as hyperaccumulative phytoremediation plants (Astragalus
praleongus, 517 μg g−1 Se, and Brassica juncea, 138 μg g−1 Se in dry sample), yeast (1200…

The metabolism of α- and γ-tocotrienol was investigated in HepG2 cells. Metabolites were
identified by HPLC and gas chromatography/mass spectrometry. γ-Tocotrienol was degraded …

Tocopherols and tocotrienols are metabolized by side chain degradation via initial ω-oxidation
and subsequent β-oxidation. ω-Oxidation is performed by cytochrome P450 (CYP) …

Bioavailability of vitamin E is influenced by several factors, most are highlighted in this review.
While gender, age and genetic constitution influence vitamin E bioavailability but cannot …

Sirtuins, a family of histone deacetylases, have a fiercely debated role in regulating lifespan.
In contrast with recent observations, here we find that overexpression of sir-2.1, the ortholog …