Ionic Regulatory Properties of Brain and Kidney Splice Variants of the Ncx1 Na+–Ca2+ Exchanger

…, BD Quednau, KD Philipson, M Hnatowich… - The Journal of general …, 1999 - rupress.org
Ion transport and regulation of Na + –Ca 2+ exchange were examined for two alternatively
spliced isoforms of the canine cardiac Na + –Ca 2+ exchanger, NCX1.1, to assess the role(s) …

Inhibition of Na+/Ca2+ exchange by KB-R7943: transport mode selectivity and antiarrhythmic consequences

…, GJ Gross, M Hnatowich… - American Journal …, 2001 - journals.physiology.org
The Na + /Ca 2+ exchanger plays a prominent role in regulating intracellular Ca 2+ levels in
cardiac myocytes and can serve as both a Ca 2+ influx and efflux pathway. A novel inhibitor, …

Adrenergic receptors. Models for regulation of signal transduction processes.

JR Raymond, M Hnatowich, RJ Lefkowitz… - Hypertension, 1990 - Am Heart Assoc
Adrenergic receptors are prototypic models for the study of the relations between structure
and function of G protein-coupled receptors. Each receptor is encoded by a distinct gene. …

SnoN as a novel negative regulator of TGF-β/Smad signaling: a target for tailoring organ fibrosis

MR Zeglinski, M Hnatowich… - American Journal of …, 2015 - journals.physiology.org
Remodeling of the extracellular matrix is beneficial during the acute wound healing stage
following tissue injury. In the short term, resident fibroblasts and myofibroblasts regulate the …

TGFβ1 regulates Scleraxis expression in primary cardiac myofibroblasts by a Smad-independent mechanism

MR Zeglinski, P Roche, M Hnatowich… - American Journal …, 2016 - journals.physiology.org
In cardiac wound healing following myocardial infarction (MI), relatively inactive resident
cardiac fibroblasts phenoconvert to hypersynthetic/secretory myofibroblasts that produce large …

Mutations of the human beta 2-adrenergic receptor that impair coupling to Gs interfere with receptor down-regulation but not sequestration.

PT Campbell, M Hnatowich, BF O'Dowd, MG Caron… - Molecular …, 1991 - ASPET
The integrity of coupling of the beta 2-adrenergic receptor (beta 2AR) to its guanine
nucleotide-binding protein, Gs, and phosphorylation events on the receptor molecule have been …

Expression of a human cDNA encoding the beta 2-adrenergic receptor in Chinese hamster fibroblasts (CHW): functionality and regulation of the expressed receptors.

M Bouvier, M Hnatowich, S Collins, BK Kobilka… - Molecular …, 1988 - ASPET
A human beta-adrenergic receptor cDNA was transfected and expressed in transformed
Chinese hamster fibroblasts (CHW). The expressed receptor exhibited a typical beta 2-…

Involvement of tyrosine residues located in the carboxyl tail of the human beta 2-adrenergic receptor in agonist-induced down-regulation of the receptor.

M Valiquette, H Bonin, M Hnatowich… - Proceedings of the …, 1990 - National Acad Sciences
Chronic exposure of various cell types to adrenergic agonists leads to a decrease in cell
surface beta 2-adrenergic receptor (beta 2AR) number. Sequestration of the receptor away from …

Inhibitory profile of SEA0400 [2-[4-[(2, 5-difluorophenyl) methoxy] phenoxy]-5-ethoxyaniline] assessed on the cardiac Na+-Ca2+ exchanger, NCX1. 1

…, T Matsuda, A Baba, K Takahashi, M Hnatowich… - … of Pharmacology and …, 2004 - ASPET
SEA0400 (2-[4-[(2,5-difluorophenyl)methoxy]phenoxy]-5-ethoxyaniline) has recently been
described as a potent and selective inhibitor of Na + -Ca 2+ exchange in cardiac, neuronal, …

[HTML][HTML] Structure-Function Analysis of CALX1. 1, a Na+-Ca2+ Exchanger fromDrosophila: MUTAGENESIS OF IONIC REGULATORY SITES

…, J Buchko, M Trac, A Omelchenko, M Hnatowich… - Journal of Biological …, 1998 - ASBMB
Cytoplasmic Na + and Ca 2+ regulate the activity of Na + -Ca 2+ exchange proteins, in addition
to serving as the transported ions, and protein regions involved in these processes have …