An increasingly large number of antiviral agents that prevent entry of human immunodeficiency
virus (HIV) into cells are in preclinical and clinical development. The envelope (Env) …

Fusion proteins of enveloped viruses categorized as class I are typified by two distinct heptad
repeat domains within the transmembrane subunit. These repeats are important structural …

The bridging sheet region of the gp120 subunit of the HIV-1 Env protein interacts with the
major virus coreceptors, CCR5 and CXCR4. We examined the impact of mutations in and …

In this study, we report the first example of a nonpeptide chemokine receptor agonist, 2-{2-[4-(3-phenoxybenzyl)piperazin-1-yl]ethoxy}ethanol
(ZK 756326), for the CC chemokine …

Characterization of the mechanisms by which HIV-1 enters cells has allowed for an increased
understanding of not only tropism and pathogenesis, but also the identification of new …

Advances into the understanding of how the human immunodeficiency virus (HIV) attaches
to and enters cells has led to a number of new anti-viral drugs that block this process. …

We previously showed that the cysteines flanking the internal fusion peptide of the avian
sarcoma/leukosis virus subtype A (ASLV-A) Env (EnvA) are important for infectivity and cell-cell …

The V1/V2 region and the V3 loop of the human immunodeficiency virus type I (HIV-1)
envelope (Env) protein are targets for neutralizing antibodies and also play an important …

The initial step of retrovirus entry—the interaction between the virus envelope glycoprotein
trimer and a cellular receptor—is complex, involving multiple, noncontiguous determinants in …

The entry process of the avian sarcoma and leukosis virus (ASLV) family of retroviruses requires
first a specific interaction between the viral surface (SU) glycoproteins and a receptor on …