Artificial niche microarrays for probing single stem cell fate in high throughput

S Gobaa, S Hoehnel, M Roccio, A Negro, S Kobel… - Nature …, 2011 - nature.com
To understand the regulatory role of niches in maintaining stem-cell fate, multifactorial in
vitro models are required. These systems should enable analysis of biochemical and …

Amino acids mediate mTOR/raptor signaling through activation of class 3 phosphatidylinositol 3OH-kinase

T Nobukuni, M Joaquin, M Roccio… - Proceedings of the …, 2005 - National Acad Sciences
During the evolution of metazoans and the rise of systemic hormonal regulation, the insulin-controlled
class 1 phosphatidylinositol 3OH-kinase (PI3K) pathway was merged with the …

Inner ear organoids: new tools to understand neurosensory cell development, degeneration and regeneration

M Roccio, ASB Edge - Development, 2019 - journals.biologists.com
The development of therapeutic interventions for hearing loss requires fundamental
knowledge about the signaling pathways controlling tissue development as well as the …

[HTML][HTML] Molecular characterization and prospective isolation of human fetal cochlear hair cell progenitors

M Roccio, M Perny, M Ealy, HR Widmer… - Nature …, 2018 - nature.com
Sensory hair cells located in the organ of Corti are essential for cochlear mechanosensation.
Their loss is irreversible in humans resulting in permanent hearing loss. The development …

[PDF][PDF] Insulin activation of Rheb, a mediator of mTOR/S6K/4E-BP signaling, is inhibited by TSC1 and 2

…, FJT Zwartkruis, T Nobukuni, M Joaquin, M Roccio… - Molecular cell, 2003 - cell.com
Tumor suppressor genes evolved as negative effectors of mitogen and nutrient signaling
pathways, such that mutations in these genes can lead to pathological states of growth. …

Metabolic control of adult neural stem cell activity by Fasn-dependent lipogenesis

…, Ö Karalay, U Suter, RAC Machado, M Roccio… - Nature, 2013 - nature.com
Mechanisms controlling the proliferative activity of neural stem and progenitor cells (NSPCs)
have a pivotal role to ensure life-long neurogenesis in the mammalian brain 1 . How …

Novel insights into inner ear development and regeneration for targeted hearing loss therapies

M Roccio, P Senn, S Heller - Hearing research, 2020 - Elsevier
Sensorineural hearing loss is the most common sensory deficit in humans. Despite the global
scale of the problem, only limited treatment options are available today. The mammalian …

Phospholipase D1 is an effector of Rheb in the mTOR pathway

…, MS Yoon, C Zhang, M Roccio… - Proceedings of the …, 2008 - National Acad Sciences
The mammalian target of rapamycin (mTOR) assembles a signaling network essential for the
regulation of cell growth, which has emerged as a major target of anticancer therapies. The …

[HTML][HTML] NANOCI—nanotechnology based cochlear implant with gapless interface to auditory neurons

P Senn, M Roccio, S Hahnewald, C Frick… - Otology & …, 2017 - journals.lww.com
Cochlear implants (CI) restore functional hearing in the majority of deaf patients. Despite the
tremendous success of these devices, some limitations remain. The bottleneck for optimal …

Predicting stem cell fate changes by differential cell cycle progression patterns

M Roccio, D Schmitter, M Knobloch, Y Okawa… - …, 2013 - journals.biologists.com
Stem cell self-renewal, commitment and reprogramming rely on a poorly understood
coordination of cell cycle progression and execution of cell fate choices. Using existing …