Artificial niche microarrays for probing single stem cell fate in high throughput
To understand the regulatory role of niches in maintaining stem-cell fate, multifactorial in
vitro models are required. These systems should enable analysis of biochemical and …
vitro models are required. These systems should enable analysis of biochemical and …
Amino acids mediate mTOR/raptor signaling through activation of class 3 phosphatidylinositol 3OH-kinase
T Nobukuni, M Joaquin, M Roccio… - Proceedings of the …, 2005 - National Acad Sciences
During the evolution of metazoans and the rise of systemic hormonal regulation, the insulin-controlled
class 1 phosphatidylinositol 3OH-kinase (PI3K) pathway was merged with the …
class 1 phosphatidylinositol 3OH-kinase (PI3K) pathway was merged with the …
Inner ear organoids: new tools to understand neurosensory cell development, degeneration and regeneration
M Roccio, ASB Edge - Development, 2019 - journals.biologists.com
The development of therapeutic interventions for hearing loss requires fundamental
knowledge about the signaling pathways controlling tissue development as well as the …
knowledge about the signaling pathways controlling tissue development as well as the …
[HTML][HTML] Molecular characterization and prospective isolation of human fetal cochlear hair cell progenitors
M Roccio, M Perny, M Ealy, HR Widmer… - Nature …, 2018 - nature.com
Sensory hair cells located in the organ of Corti are essential for cochlear mechanosensation.
Their loss is irreversible in humans resulting in permanent hearing loss. The development …
Their loss is irreversible in humans resulting in permanent hearing loss. The development …
[PDF][PDF] Insulin activation of Rheb, a mediator of mTOR/S6K/4E-BP signaling, is inhibited by TSC1 and 2
…, FJT Zwartkruis, T Nobukuni, M Joaquin, M Roccio… - Molecular cell, 2003 - cell.com
Tumor suppressor genes evolved as negative effectors of mitogen and nutrient signaling
pathways, such that mutations in these genes can lead to pathological states of growth. …
pathways, such that mutations in these genes can lead to pathological states of growth. …
Metabolic control of adult neural stem cell activity by Fasn-dependent lipogenesis
…, Ö Karalay, U Suter, RAC Machado, M Roccio… - Nature, 2013 - nature.com
Mechanisms controlling the proliferative activity of neural stem and progenitor cells (NSPCs)
have a pivotal role to ensure life-long neurogenesis in the mammalian brain 1 . How …
have a pivotal role to ensure life-long neurogenesis in the mammalian brain 1 . How …
Novel insights into inner ear development and regeneration for targeted hearing loss therapies
Sensorineural hearing loss is the most common sensory deficit in humans. Despite the global
scale of the problem, only limited treatment options are available today. The mammalian …
scale of the problem, only limited treatment options are available today. The mammalian …
Phospholipase D1 is an effector of Rheb in the mTOR pathway
The mammalian target of rapamycin (mTOR) assembles a signaling network essential for the
regulation of cell growth, which has emerged as a major target of anticancer therapies. The …
regulation of cell growth, which has emerged as a major target of anticancer therapies. The …
[HTML][HTML] NANOCI—nanotechnology based cochlear implant with gapless interface to auditory neurons
P Senn, M Roccio, S Hahnewald, C Frick… - Otology & …, 2017 - journals.lww.com
Cochlear implants (CI) restore functional hearing in the majority of deaf patients. Despite the
tremendous success of these devices, some limitations remain. The bottleneck for optimal …
tremendous success of these devices, some limitations remain. The bottleneck for optimal …
Predicting stem cell fate changes by differential cell cycle progression patterns
M Roccio, D Schmitter, M Knobloch, Y Okawa… - …, 2013 - journals.biologists.com
Stem cell self-renewal, commitment and reprogramming rely on a poorly understood
coordination of cell cycle progression and execution of cell fate choices. Using existing …
coordination of cell cycle progression and execution of cell fate choices. Using existing …