User profiles for Martin J. Main

MJ Main

Head of Molecular Technologies, Medicines Discovery Catapult
Verified email at md.catapult.org.uk
Cited by 6503

RAMPs regulate the transport and ligand specificity of the calcitonin-receptor-like receptor

LM McLatchie, NJ Fraser, MJ Main, A Wise, J Brown… - Nature, 1998 - nature.com
Calcitonin-gene-related peptide (CGRP) and adrenomedullin are related peptides with
distinct pharmacological profiles. Here we show that a receptor with seven transmembrane …

Heterodimerization is required for the formation of a functional GABAB receptor

JH White, A Wise, MJ Main, A Green, NJ Fraser… - Nature, 1998 - nature.com
GABA (γ-aminobutyric acid) is the main inhibitory neurotransmitter in the mammalian central
nervous system, where it exerts its effects through ionotropic (GABA A/C ) receptors to …

Multiple amylin receptors arise from receptor activity-modifying protein interaction with the calcitonin receptor gene product

…, N Tilakaratne, Y Gao, NJ Fraser, MJ Main… - Molecular …, 1999 - ASPET
Receptor activity-modifying proteins (RAMPs) are single-transmembrane proteins that
transport the calcitonin receptor-like receptor (CRLR) to the cell surface. RAMP 1-transported …

Modulation of KCNQ2/3 potassium channels by the novel anticonvulsant retigabine

MJ Main, JE Cryan, JRB Dupere, B Cox, JJ Clare… - Molecular …, 2000 - ASPET
Retigabine is a novel anticonvulsant with an unknown mechanism of action. It has recently
been reported that retigabine modulates a potassium channel current in nerve growth factor-…

Acute and late outcomes of unprotected left main stenting in comparison with surgical revascularization

…, L Rzeszutko, P Buszman, J Szymszal, JL Martin… - Journal of the American …, 2008 - jacc.org
Objectives : The purpose of this study was to compare the early and late results of
percutaneous and surgical revascularization of left main coronary artery stenosis. Background : …

Biopolymer-clay nanocomposites as novel and ecofriendly adsorbents for environmental remediation

M del Mar Orta, J Martín, JL Santos, I Aparicio… - Applied Clay …, 2020 - Elsevier
… First, the physicochemical and structural properties of clays and biopolymers as well as
the main characterization and preparation techniques are discussed. Subsequently, the main

Biogeographical patterns in the diet of an opportunistic predator: the red fox Vulpes vulpes in the Iberian Peninsula

…, JL García‐Moreno, J María López‐Martín… - Mammal …, 2013 - Wiley Online Library
main … of main food groups in relation to geographical variables (latitude, longitude and
altitude); (ii) analysed the relationships between red fox dietary diversity, consumption of its main

Ordered magnetic nanostructures: fabrication and properties

JI Martın, J Nogues, K Liu, JL Vicent… - Journal of magnetism and …, 2003 - Elsevier
The fabrication methods and physical properties of ordered magnetic nanostructures with
dimensions on the submicron to nanometer scale are reviewed. First, various types of …

[BOOK][B] Rapid application development

J Martin - 1991 - dl.acm.org
… This history column article provides a tour of the main software development life cycle (SDLC)
models. (A lifecycle covers all the stages of software from its inception with requirements …

Energy management of a fuel cell/supercapacitor/battery power source for electric vehicular applications

M Zandi, A Payman, JP Martin… - IEEE transactions on …, 2010 - ieeexplore.ieee.org
… This EHPS is composed of a Fuel Cell system (FC) as the main … manage the energy between
the main and the auxiliary sources and … The main property of this strategy is that the energy …