User profiles for Matthew D. Breyer
Matthew BreyerJanssen pharmaceutical Verified email at its.jnj.com Cited by 24113 |
Prostanoid receptors: subtypes and signaling
Cyclooxygenases metabolize arachidonate to five primary prostanoids: PGE 2 , PGF 2α , PGI
2 , TxA 2 , and PGD 2 . These autacrine lipid mediators interact with specific members of a …
2 , TxA 2 , and PGD 2 . These autacrine lipid mediators interact with specific members of a …
Cyclooxygenase-2 is associated with the macula densa of rat kidney and increases with salt restriction.
The kidney is a rich source of prostaglandins. These eicosanoids, formed by
cyclooxygenase-dependent metabolism of arachidonic acid, are important physiologic mediators of …
cyclooxygenase-dependent metabolism of arachidonic acid, are important physiologic mediators of …
Thiazolidinediones expand body fluid volume through PPARγ stimulation of ENaC-mediated renal salt absorption
…, MA Magnuson, R Redha, Y Zhang, MD Breyer - Nature medicine, 2005 - nature.com
Thiazolidinediones (TZDs) are widely used to treat type 2 diabetes mellitus; however, their
use is complicated by systemic fluid retention. Along the nephron, the pharmacological target …
use is complicated by systemic fluid retention. Along the nephron, the pharmacological target …
Mouse models of diabetic nephropathy
MD Breyer, E Bo, FC Brosius III… - Journal of the …, 2005 - journals.lww.com
Mice provide an experimental model of unparalleled flexibility for studying mammalian
diseases. Inbred strains of mice exhibit substantial differences in their susceptibility to the renal …
diseases. Inbred strains of mice exhibit substantial differences in their susceptibility to the renal …
Mouse models of diabetic nephropathy
Diabetic nephropathy is a major cause of ESRD worldwide. Despite its prevalence, a lack of
reliable animal models that mimic human disease has delayed the identification of specific …
reliable animal models that mimic human disease has delayed the identification of specific …
Salt–sensitive hypertension and reduced fertility in mice lacking the prostaglandin EP2 receptor
Prostaglandins (PGs) are ubiquitous lipid mediators derived from cyclooxygenase metabolism
of arachidonic acid that exert a broad range of physiologic activities, including modulation …
of arachidonic acid that exert a broad range of physiologic activities, including modulation …
[HTML][HTML] Peroxisome proliferator-activated receptors (PPARs): novel therapeutic targets in renal disease
YF Guan, MD Breyer - Kidney international, 2001 - Elsevier
… The D hinge region is a docking domain for cofactors. The E/F C-terminal region contains
two important domains. One is the ligand-binding domain (LBD), or E domain, responsible for …
two important domains. One is the ligand-binding domain (LBD), or E domain, responsible for …
[PDF][PDF] Mapping the single-cell transcriptomic response of murine diabetic kidney disease to therapies
Diabetic kidney disease (DKD) occurs in ∼40% of patients with diabetes and causes kidney
failure, cardiovascular disease, and premature death. We analyzed the response of a …
failure, cardiovascular disease, and premature death. We analyzed the response of a …
Endothelial nitric oxide synthase deficiency produces accelerated nephropathy in diabetic mice
Functionally significant polymorphisms in endothelial nitric oxide synthase (eNOS) and
reduced vascular eNOS activity have been associated with increased human diabetic …
reduced vascular eNOS activity have been associated with increased human diabetic …
Serial determination of glomerular filtration rate in conscious mice using FITC-inulin clearance
Two nonradioactive methods for determining glomerular filtration rate (GFR) in conscious
mice using FITC-labeled inulin (FITC-inulin) were evaluated. The first method measured GFR …
mice using FITC-labeled inulin (FITC-inulin) were evaluated. The first method measured GFR …