DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis
…, A Krämer, F Tort, K Zieger, P Guldberg, M Sehested… - Nature, 2005 - nature.com
During the evolution of cancer, the incipient tumour experiences ‘oncogenic stress’, which
evokes a counter-response to eliminate such hazardous cells. However, the nature of this …
evokes a counter-response to eliminate such hazardous cells. However, the nature of this …
Oncogene-induced senescence is part of the tumorigenesis barrier imposed by DNA damage checkpoints
…, F Tort, K Fugger, F Johansson, M Sehested… - Nature, 2006 - nature.com
Recent studies have indicated the existence of tumorigenesis barriers that slow or inhibit
the progression of preneoplastic lesions to neoplasia. One such barrier involves DNA …
the progression of preneoplastic lesions to neoplasia. One such barrier involves DNA …
Determination of the class and isoform selectivity of small-molecule histone deacetylase inhibitors
…, PB Jensen, HS Lichenstein, M Sehested - Biochemical …, 2008 - portlandpress.com
The human HDAC (histone deacetylase) family, a well-validated anticancer target, plays a
key role in the control of gene expression through regulation of transcription. While HDACs …
key role in the control of gene expression through regulation of transcription. While HDACs …
Inhibition of human Chk1 causes increased initiation of DNA replication, phosphorylation of ATR targets, and DNA breakage
…, F Johansson, T Helleday, M Sehested… - … and cellular biology, 2005 - Am Soc Microbiol
Human checkpoint kinase 1 (Chk1) is an essential kinase required to preserve genome
stability. Here, we show that Chk1 inhibition by two distinct drugs, UCN-01 and CEP-3891, or by …
stability. Here, we show that Chk1 inhibition by two distinct drugs, UCN-01 and CEP-3891, or by …
53BP1 functions in an ATM-dependent checkpoint pathway that is constitutively activated in human cancer
…, TA Mochan, M Venere, J Bartkova, M Sehested… - Nature cell …, 2002 - nature.com
53BP1 is a conserved nuclear protein that is implicated in the DNA damage response. After
irradiation, 53BP1 localizes rapidly to nuclear foci, which represent sites of DNA double …
irradiation, 53BP1 localizes rapidly to nuclear foci, which represent sites of DNA double …
Neutrophil gelatinase-associated lipocalin is up-regulated in human epithelial cells by IL-1β, but not by TNF-α
JB Cowland, OE Sørensen, M Sehested… - The Journal of …, 2003 - journals.aai.org
Synthesis of the antimicrobial protein neutrophil gelatinase-associated lipocalin (NGAL)
increases dramatically in bronchial epithelial cells and alveolear type II pneumocytes during …
increases dramatically in bronchial epithelial cells and alveolear type II pneumocytes during …
Biosynthesis of granule proteins in normal human bone marrow cells. Gelatinase is a marker of terminal neutrophil differentiation
N Borregaard, M Sehested, BS Nielsen, H Sengelov… - 1995 - ashpublications.org
Differentiation and maturation of myeloid cells is characterized by the sequential acquisition
of two distinct cytoplasmic granule subsets, azurophil granules and specific granules. We …
of two distinct cytoplasmic granule subsets, azurophil granules and specific granules. We …
[HTML][HTML] Quantitative proteomic analysis of post-translational modifications of human histones
…, R Matthiesen, LH Jensen, M Sehested… - Molecular & Cellular …, 2006 - ASBMB
Histone proteins are subject to a range of post-transcriptional modifications in living cells.
The combinatorial nature of these modifications constitutes the "histone code" that dictates …
The combinatorial nature of these modifications constitutes the "histone code" that dictates …
Culprit and victim–DNA topoisomerase II
U Kellner, M Sehested, PB Jensen, F Gieseler… - The lancet …, 2002 - thelancet.com
The phylogenetic antiquity of DNA topoisomerases indicates their vital function. Structure and
maintenance of genomic DNA depend on the activity of these enzymes, and without them …
maintenance of genomic DNA depend on the activity of these enzymes, and without them …
[HTML][HTML] Essential mitotic functions of DNA topoisomerase IIα are not adopted by topoisomerase IIβ in human H69 cells
P Grue, A Gräßer, M Sehested, PB Jensen… - Journal of Biological …, 1998 - ASBMB
Unique functions of mammalian DNA-topoisomerases IIα and -β are suggested by their distinct
cellular distribution and chromatin binding at mitosis. Here, we studied H69-VP cells that, …
cellular distribution and chromatin binding at mitosis. Here, we studied H69-VP cells that, …