[HTML][HTML] Discovery of novel small molecule inhibitors of S100P with in vitro anti-metastatic effects on pancreatic cancer cells
R Camara, D Ogbeni, L Gerstmann, M Ostovar… - European Journal of …, 2020 - Elsevier
S100P, a calcium-binding protein, is known to advance tumor progression and metastasis
in pancreatic and several other cancers. Herein is described the in silico identification of a …
in pancreatic and several other cancers. Herein is described the in silico identification of a …
[PDF][PDF] Palladium‐Mediated Annulation of Vinyl Aziridines with Michael Acceptors: Stereocontrolled Synthesis of Substituted Pyrrolidines and Its Application in a …
MA Lowe, M Ostovar, S Ferrini, CC Chen… - Angewandte Chemie …, 2011 - bristol.ac.uk
The rapid increase in molecular complexity from simple precursors is a major goal in organic
synthesis.[1] Within this context, the palladium-mediated annulation reaction of Michael …
synthesis.[1] Within this context, the palladium-mediated annulation reaction of Michael …
Practical and highly selective sulfur ylide-mediated asymmetric epoxidations and aziridinations using a cheap and readily available chiral sulfide: Extensive studies to …
O Illa, M Namutebi, C Saha, M Ostovar… - Journal of the …, 2013 - ACS Publications
The chiral sulfide, isothiocineole, has been synthesized in one step from elemental sulfur, γ-terpinene,
and limonene in 61% yield. A mechanism involving radical intermediates for this …
and limonene in 61% yield. A mechanism involving radical intermediates for this …
Role of G protein–coupled receptor kinases 2 and 3 in μ-opioid receptor desensitization and internalization
JD Lowe, HS Sanderson, AE Cooke, M Ostovar… - Molecular …, 2015 - ASPET
There is ongoing debate about the role of G protein–coupled receptor kinases (GRKs) in
agonist-induced desensitization of the μ-opioid receptor (MOPr) in brain neurons. In the present …
agonist-induced desensitization of the μ-opioid receptor (MOPr) in brain neurons. In the present …
Evaluating academic answers generated using ChatGPT
S Fergus, M Botha, M Ostovar - Journal of Chemical Education, 2023 - ACS Publications
The integration of technology in education has become ever more prioritized since the
COVID-19 pandemic. Chat Generative Pre-Trained Transformer (ChatGPT) is an artificial …
COVID-19 pandemic. Chat Generative Pre-Trained Transformer (ChatGPT) is an artificial …
Enantioselective synthesis of the cyclopiazonic acid family using sulfur ylides
…, M Ferrara, M Ahmad, M Ostovar… - Angewandte Chemie …, 2018 - Wiley Online Library
A convergent, nine‐step (LLS), enantioselective synthesis of α‐cyclopiazonic acid and related
natural products is reported. The route features a) an enantioselective aziridination of an …
natural products is reported. The route features a) an enantioselective aziridination of an …
Characterization of BU09059: a novel potent selective κ-receptor antagonist
JJ Casal-Dominguez, D Furkert, M Ostovar… - ACS chemical …, 2014 - ACS Publications
Kappa-opioid receptor (κ) antagonists are potential therapeutic agents for a range of
psychiatric disorders. The feasibility of developing κ-antagonists has been limited by the …
psychiatric disorders. The feasibility of developing κ-antagonists has been limited by the …
The buprenorphine analogue BU10119 attenuates drug-primed and stress-induced cocaine reinstatement in mice
…, LG Rysztak, BF Sears, C Meurice, M Ostovar… - … of Pharmacology and …, 2021 - ASPET
There are no Food and Drug Administration–approved medications for cocaine use disorder,
including relapse. The μ-opioid receptor (MOPr) partial agonist buprenorphine alone or in …
including relapse. The μ-opioid receptor (MOPr) partial agonist buprenorphine alone or in …
Antidepressant‐like effects of BU10119, a novel buprenorphine analogue with mixed κ/μ receptor antagonist properties, in mice
A Almatroudi, M Ostovar, CP Bailey… - British Journal of …, 2018 - Wiley Online Library
Background and Purpose The κ receptor antagonists have potential for treating neuropsychiatric
disorders. We have investigated the in vivo pharmacology of a novel buprenorphine …
disorders. We have investigated the in vivo pharmacology of a novel buprenorphine …
C7β-methyl analogues of the orvinols: the discovery of kappa opioid antagonists with nociceptin/orphanin FQ peptide (NOP) receptor partial agonism and low, or zero …
Buprenorphine is a successful analgesic and treatment for opioid abuse, with both activities
relying on its partial agonist activity at mu opioid receptors. However, there is substantial …
relying on its partial agonist activity at mu opioid receptors. However, there is substantial …