The synaptic vesicle cycle revisited: new insights into the modes and mechanisms
NL Chanaday, MA Cousin, I Milosevic… - Journal of …, 2019 - Soc Neuroscience
Neurotransmission is sustained by endocytosis and refilling of synaptic vesicles (SVs) locally
within the presynapse. Until recently, a consensus formed that after exocytosis, SVs are …
within the presynapse. Until recently, a consensus formed that after exocytosis, SVs are …
The dephosphins: dephosphorylation by calcineurin triggers synaptic vesicle endocytosis
MA Cousin, PJ Robinson - Trends in neurosciences, 2001 - cell.com
When nerve terminals in the brain are stimulated, a group of phosphoproteins called the
dephosphins are coordinately dephosphorylated by calcineurin, the Ca 2+ -dependent protein …
dephosphins are coordinately dephosphorylated by calcineurin, the Ca 2+ -dependent protein …
Cdk5 is essential for synaptic vesicle endocytosis
…, B Sarcevic, RA Boadle, MR Larsen, MA Cousin… - Nature cell …, 2003 - nature.com
Synaptic vesicle endocytosis (SVE) is triggered by calcineurin-mediated dephosphorylation
of the dephosphin proteins. SVE is maintained by the subsequent rephosphorylation of the …
of the dephosphin proteins. SVE is maintained by the subsequent rephosphorylation of the …
Syndapin I is the phosphorylation-regulated dynamin I partner in synaptic vesicle endocytosis
…, KJ Smillie, ME Graham, VA Valova, MA Cousin… - Nature …, 2006 - nature.com
Dynamin I is dephosphorylated at Ser-774 and Ser-778 during synaptic vesicle endocytosis
(SVE) in nerve terminals. Phosphorylation was proposed to regulate the assembly of an …
(SVE) in nerve terminals. Phosphorylation was proposed to regulate the assembly of an …
Dynamin I phosphorylation by GSK3 controls activity-dependent bulk endocytosis of synaptic vesicles
…, C Sutherland, PJ Robinson, MA Cousin - Nature …, 2010 - nature.com
Glycogen synthase kinase 3 (GSK3) is a critical enzyme in neuronal physiology; however, it
is not yet known whether it has any specific role in presynaptic function. We found that GSK3 …
is not yet known whether it has any specific role in presynaptic function. We found that GSK3 …
The molecular physiology of activity‐dependent bulk endocytosis of synaptic vesicles
EL Clayton, MA Cousin - Journal of neurochemistry, 2009 - Wiley Online Library
Central nerve terminals release neurotransmitter in response to a wide variety of stimuli.
Because maintenance of neurotransmitter release is dependent on the continual supply of …
Because maintenance of neurotransmitter release is dependent on the continual supply of …
[PDF][PDF] VAMP4 is an essential cargo molecule for activity-dependent bulk endocytosis
The accurate formation of synaptic vesicles (SVs) and incorporation of their protein cargo
during endocytosis is critical for the maintenance of neurotransmission. During intense …
during endocytosis is critical for the maintenance of neurotransmission. During intense …
Building a better dynasore: the dyngo compounds potently inhibit dynamin and endocytosis
…, FM Deane, TH Nguyen, FA Meunier, MA Cousin… - Traffic, 2013 - Wiley Online Library
Dynamin GTPase activity increases when it oligomerizes either into helices in the presence
of lipid templates or into rings in the presence of SH3 domain proteins. Dynasore is a …
of lipid templates or into rings in the presence of SH3 domain proteins. Dynasore is a …
Bulk synaptic vesicle endocytosis is rapidly triggered during strong stimulation
EL Clayton, GJO Evans, MA Cousin - Journal of Neuroscience, 2008 - Soc Neuroscience
Bulk endocytosis in central nerve terminals is activated by strong stimulation; however, the
speed at which it is initiated and for how long it persists is still a matter of debate. To resolve …
speed at which it is initiated and for how long it persists is still a matter of debate. To resolve …
The phospho-dependent dynamin–syndapin interaction triggers activity-dependent bulk endocytosis of synaptic vesicles
…, N Chau, PJ Robinson, MA Cousin - Journal of …, 2009 - Soc Neuroscience
Synaptic vesicles (SVs) are retrieved by more than one mode in central nerve terminals.
During mild stimulation, the dominant SV retrieval pathway is classical clathrin-mediated …
During mild stimulation, the dominant SV retrieval pathway is classical clathrin-mediated …