Molecular mimicry has been proposed as a pathogenetic mechanism for autoimmune disease,
as well as a probe useful in uncovering its etiologic agents. The hypothesis is based in …

The influenza pandemic of 1918 killed nearly 50 million people worldwide and was
characterized by an atypical W-shaped mortality curve, where adults between the ages of 30–60 …

The sphingosine-1-phosphate (S1P) receptor signaling system has biological and medical
importance and is the first lipid G protein–coupled receptor (GPCR) structure to be solved to …

The HIV-1-specific cytotoxic T lymphocyte (CTL) response is temporally associated with the
decline in viremia during primary HIV-1 infection, but definitive evidence that it is of …

Amino acid sequence homology was found between viral and host encephalitogenic protein.
Immune responses were then generated in rabbits by using the viral peptide that cross-…

Persistent viral infections are a major health concern. One obstacle inhibiting the clearance
of persistent infections is functional inactivation of antiviral T cells. Although such …

We investigated the potential association between viruses and insulin-dependent(type 1)
diabetes (IDDM) by developing a transgenic mouse model. By inserting into these mice a …

A peripheral membrane protein that is interactive with lymphocytic choriomeningitis virus (LCMV)
was purified from cells permissive to infection. Tryptic peptides from this protein were …

The activation of Toll-like receptors (TLRs) in dendritic cells (DCs) triggers a rapid inflammatory
response to pathogens. However, this response must be tightly regulated because …

During persistent viral infections, chronic immune activation, negative immune regulator
expression, an elevated interferon signature, and lymphoid tissue destruction correlate with …