Rapamycin causes poorly reversible inhibition of mTOR and induces p53-independent apoptosis in human rhabdomyosarcoma cells
H Hosoi, MB Dilling, T Shikata, LN Liu, L Shu… - Cancer research, 1999 - AACR
The mammalian target of rapamycin (mTOR) has been shown to link growth factor signaling
and posttranscriptional control of translation of proteins that are frequently involved in cell …
and posttranscriptional control of translation of proteins that are frequently involved in cell …
Biochemical correlates of mTOR inhibition by the rapamycin ester CCI-779 and tumor growth inhibition
L Dudkin, MB Dilling, PJ Cheshire, FC Harwood… - Clinical Cancer …, 2001 - AACR
The rapamycin ester, CCI-779, potently inhibits cell growth in vitro, inhibits tumor growth in
vivo, and is currently in Phase I clinical trials. To further understand the relationship between …
vivo, and is currently in Phase I clinical trials. To further understand the relationship between …
[PDF][PDF] Sustained activation of the JNK cascade and rapamycin-induced apoptosis are suppressed by p53/p21Cip1
S Huang, L Shu, MB Dilling, J Easton, FC Harwood… - Molecular cell, 2003 - cell.com
Under serum-free conditions, rapamycin, an inhibitor of mammalian target of rapamycin (mTOR),
induces apoptosis of cells lacking functional p53. Cells expressing wild-type p53 or p21 …
induces apoptosis of cells lacking functional p53. Cells expressing wild-type p53 or p21 …
p53/p21CIP1 Cooperate in Enforcing Rapamycin-induced G1 Arrest and Determine the Cellular Response to Rapamycin
S Huang, LN Liu, H Hosoi, MB Dilling, T Shikata… - Cancer research, 2001 - AACR
The relationship between G 1 checkpoint function and rapamycininduced apoptosis was
examined using two human rhabdomyosarcoma cell lines, Rh1 and Rh30, that express …
examined using two human rhabdomyosarcoma cell lines, Rh1 and Rh30, that express …
Rapamycin selectively inhibits the growth of childhood rhabdomyosarcoma cells through inhibition of signaling via the type I insulin-like growth factor receptor
MB Dilling, P Dias, DN Shapiro, GS Germain… - Cancer research, 1994 - AACR
We show that cell lines derived from childhood alveolar rhabdomyosarcoma (RMS) are very
sensitive to the growth-inhibitory effects of the immunosuppressive agent rapamycin (RAP), …
sensitive to the growth-inhibitory effects of the immunosuppressive agent rapamycin (RAP), …
Studies on the mechanism of resistance to rapamycin in human cancer cells
H Hosoi, MB Dilling, LN Liu, MK Danks, T Shikata… - Molecular …, 1998 - ASPET
Rapamycin is a potent cytostatic agent that arrests cells in the G1 phase of the cell cycle. The
relationships between cellular sensitivity to rapamycin, drug accumulation, expression of …
relationships between cellular sensitivity to rapamycin, drug accumulation, expression of …
[HTML][HTML] 4E-binding proteins, the suppressors of eukaryotic initiation factor 4E, are down-regulated in cells with acquired or intrinsic resistance to rapamycin
MB Dilling, GS Germain, L Dudkin… - Journal of Biological …, 2002 - ASBMB
To determine whether inhibition of either the ribosomal p70 S6 kinase or eukaryotic
initiation factor (eIF) 4E pathways downstream of the mammalian target of rapamycin, mTOR, …
initiation factor (eIF) 4E pathways downstream of the mammalian target of rapamycin, mTOR, …
The influence of recombinant human insulin-like growth factor-I (rhIGF-I) on cell growth and cytotoxicity of drugs in childhood rhabdomyosarcoma cell lines and …
CEM Gidding, GS Germain, MB Dilling… - Cancer chemotherapy …, 2000 - Springer
Purpose: Recombinant human insulin-like growth factor I (rhIGF-I) has been reported to
ameliorate vincristine-induced neuropathy, the dose-limiting side effect of this antimitotic …
ameliorate vincristine-induced neuropathy, the dose-limiting side effect of this antimitotic …
Formulating Industry-Academic Collaborations That Work: Best Practices to Ensure a Strong Relationship After the Agreements Are Signed
MB Dilling, AC DiSante, R Durland… - Technology & …, 2020 - ingentaconnect.com
Collaborations between academia and industry are growing in scope, duration, and
sophistication. The best collaborations recognize the unique strengths and skill sets of both parties …
sophistication. The best collaborations recognize the unique strengths and skill sets of both parties …
[CITATION][C] Regular Articles-Experimental Therapeutics-p53/p21C1P1 Cooperate in Enforcing Rapamycin-induced G1 Arrest and Determine the Cellular Response to …
S Huang, LN Liu, H Hosoi, MB Dilling… - Cancer …, 2001 - Baltimore, Md.: Waverly Press