Solid-phase peptide synthesis: from standard procedures to the synthesis of difficult sequences

I Coin, M Beyermann, M Bienert - Nature protocols, 2007 - nature.com
This protocol for solid-phase peptide synthesis (SPPS) is based on the widely used Fmoc/tBu
strategy, activation of the carboxyl groups by aminium-derived coupling reagents and use …

Cellular uptake of an α-helical amphipathic model peptide with the potential to deliver polar compounds into the cell interior non-endocytically

…, A Scheller, B Wiesner, E Krause, M Beyermann… - … et Biophysica Acta (BBA …, 1998 - Elsevier
Cellular uptake of an a-helical amphipathic model peptide with the potential to deliver polar
compounds into the cell interior n Page 1 ELSEVIER Biochimica et Biophysica Acta 1414 (…

Peptide helicity and membrane surface charge modulate the balance of electrostatic and hydrophobic interactions with lipid bilayers and biological membranes

…, T Wieprecht, A Winkler, M Beyermann… - Biochemistry, 1996 - ACS Publications
An amphipathic model peptide, KLALKLALKALKAAKLA-NH 2 , and its complete double d-amino
acid replacement set was used to analyze the process of peptide binding at lipid …

[HTML][HTML] Optimization of the antimicrobial activity of magainin peptides by modification of charge

M Dathe, H Nikolenko, J Meyer, M Beyermann… - FEBS letters, 2001 - Elsevier
Investigation of magainin II amide analogs with cationic charges ranging between +3 and +7
showed that enhancement of the peptide charge up to a threshold value of +5 and …

[HTML][HTML] Hydrophobicity, hydrophobic moment and angle subtended by charged residues modulate antibacterial and haemolytic activity of amphipathic helical …

…, L Handel, WL Maloy, DL MacDonald, M Beyermann… - FEBS letters, 1997 - Elsevier
The hydrophobicity (H), hydrophobic moment (μ) and the angle subtended by the positively
charged helix face (Φ) of a set of model and magainin2amide peptides with conserved …

[PDF][PDF] The uronium/guanidinium peptide coupling reagents: finally the true uronium salts

…, H Wenschuh, J Klose, M Beyermann… - Angewandte Chemie …, 2002 - users.uniwa.gr
Among the currently most popular peptide coupling reagents are the phosphonium [1, 2](BOP,
PyBOP, etc.) and guanidinium [3](HBTU, HATU, etc.) salts. When first described in 1978, …

Peptide hydrophobicity controls the activity and selectivity of magainin 2 amide in interaction with membranes

T Wieprecht, M Dathe, M Beyermann, E Krause… - Biochemistry, 1997 - ACS Publications
The magainins are antibacterial peptides from the skin of Xenopus laevis. They show a broad
range of activity against prokaryotic cells but lyse eukaryotic cells poorly. To elucidate the …

Highly conserved and disease‐specific patterns of carboxyterminally truncated Aβ peptides 1–37/38/39 in addition to 1–40/42 in Alzheimer's disease and in patients …

…, T Dyrks, M Bienert, M Beyermann… - Journal of …, 2002 - Wiley Online Library
Human lumbar CSF patterns of Aβ peptides were analysed by urea‐based β‐amyloid
sodium dodecyl sulphate polyacrylamide gel electrophoresis with western immunoblot (Aβ‐SDS–…

Peptide synthesis via amino acid halides

LA Carpino, M Beyermann, H Wenschuh… - Accounts of chemical …, 1996 - ACS Publications
Michael Beyermann was born in 1953 in Berlin. He studied at the Humboldt University,
obtaining his Ph.D. … Michael Bienert at the FMP, obtaining his Ph.D. in 1995 on a project …

Immobilization reduces the activity of surface-bound cationic antimicrobial peptides with no influence upon the activity spectrum

M Bagheri, M Beyermann, M Dathe - Antimicrobial agents and …, 2009 - Am Soc Microbiol
Early studies of immobilized peptides mainly focused upon the relationship between structural
properties and the activity of soluble and surface-tethered sequences. The intention of this …