Essential metals, such as iron and copper, play a critical role in a plethora of cellular processes
including cell growth and proliferation. However, concomitantly, excess of these metal …

Copper is an essential trace metal required by organisms to perform a number of important
biological processes. Copper readily cycles between its reduced Cu(i) and oxidised Cu(ii) …

A major problem for cancer patients is the metastasis of cancer cells from the primary tumor.
This involves:(1) migration through the basement membrane;(2) dissemination via the …

The metastasis suppressor, N-myc downstream-regulated gene-1 (NDRG1), plays multifaceted
roles in inhibiting oncogenic signaling and can suppress the epithelial mesenchymal …

Metastasis is a complex process that is regulated by multiple signaling pathways, with the
focal adhesion kinase (FAK)/paxillin pathway playing a major role in the formation of focal …

Friedreich’s ataxia is a cardio- and neurodegenerative disease due to decreased expression
of the mitochondrial protein, frataxin. This defect results in mitochondrial iron-overload, and …

Multidrug resistance (MDR) is a major obstacle in cancer treatment due to the ability of tumor
cells to efflux chemotherapeutics via drug transporters (eg P-glycoprotein (Pgp; ABCB1)). …

The rise in drug-resistant strains of Mycobacterium tuberculosis is a major threat to human
health and highlights the need for new therapeutic strategies. In this study, we have assessed …

Di-2-pyridylketone 4, 4-dimethyl-3-thiosemicarbazone (Dp44mT) demonstrates potent anti-cancer
activity. We previously demonstrated that 14 C-Dp44mT enters and targets cells …

Aims Mitochondrial damage is implicated in diabetes pathogenesis and complications.
Mitochondrial DNA copy number (mtDNA-cn) in human Type 1 diabetes (T1D) studies are lacking…