PURPOSE The CLL14 study has established one-year fixed-duration treatment of venetoclax
and obinutuzumab (Ven-Obi) for patients with previously untreated chronic lymphocytic …

Purpose: Metastatic castration-resistant prostate cancer (mCRPC) remains a disease with
high unmet medical need, as most patients do not achieve durable response with available …

Antibody–drug conjugates (ADCs) combine the specificity of an antibody with the cytotoxicity
of a chemical agent. They represent a rapidly evolving area of oncology drug development …

This study’s primary objective was to fully characterize the pharmacokinetics of metformin in
pregnant women with gestational diabetes mellitus (GDM) versus nonpregnant controls. …

Recombinant adeno‐associated virus (AAV) is currently the most widely used platform for in
vivo gene therapy. Clinical pharmacology is a central field for AAV gene therapy, …

25-hydroxyvitamin D 3 -3-sulfate (25-OHD 3 -S) and 25-hydroxyvitamin D 3 -3-glucuronide (25-OHD
3 -G) are major conjugative metabolites of vitamin D 3 found in the systemic …

… Multiple reaction monitoring transitions for each analyte and internal standard were m/z 414.2
> 83.1 for NBUP, m/z 590.3 > 414.2 for NBUP-G, and m/z 417.2 > 83.1for NBUP-d3. NBUP-…

Vitamin D 3 is an important prohormone critical for maintaining calcium and phosphate
homeostasis in the body and regulating drug-metabolizing enzymes and transporters. 25-…

Opioid dependence during pregnancy is a rising concern. Maintaining addicted pregnant
women on long-acting opioid receptor agonist is the most common strategy to manage drug …

Adoptive cell therapies (ACTs) have shown transformative efficacy in oncology with five US
Food and Drug Administration (FDA) approvals for chimeric antigen receptor (CAR) T‐cell …