Heterotrimeric G proteins are molecular switches that control signal transduction. Ligand-occupied,
G protein-coupled receptors serve as the canonical guanine nucleotide exchange …

Bag3, a nucleotide exchange factor of the heat shock protein Hsp70, has been implicated in
cell signaling. Here, we report that Bag3 interacts with the SH3 domain of Src, thereby …

During migration, cells must couple direction sensing to signal transduction and actin remodeling.
We previously identified GIV/Girdin as a Gαi3 binding partner. We demonstrate that in …

Cells respond to growth factors by either migrating or proliferating, but not both at the same
time, a phenomenon termed migration-proliferation dichotomy. The underlying mechanism of …

10.7554/eLife.07091.001 Wnt signaling is essential for tissue homeostasis and its
dysregulation causes cancer. Wnt ligands trigger signaling by activating Frizzled receptors (FZDRs), …

… In this work we describe GIV, a nonreceptor GEF for Gα i3 (Garcia-Marcos et al., 2009), as
a … and specifically disrupts GIV’s GEF activity (Garcia-Marcos et al., 2009), we conclude that …

Heterotrimeric G-proteins (Gαβγ) are the main transducers of signals from GPCRs, mediating
the action of countless natural stimuli and therapeutic agents. However, there are currently …

Activation of trimeric G proteins has been traditionally viewed as the exclusive job of G
protein-coupled receptors (GPCRs). This view has been challenged by the discovery of non-…

Metastasis accounts for the majority of cancer-related deaths. Accurate prediction of
metastatic potential of tumors has been elusive, and the search for clinically useful markers …

Although several non-receptor activators of heterotrimeric G proteins have been identified,
the structural features of G proteins that determine their interaction with such activators and …