Lipid biomarkers in Alzheimer's disease

…, M Cherkaoui-Malki, M El Ayeb… - Current Alzheimer …, 2018 - ingentaconnect.com
Background: There are now significant evidences that lipid metabolism is affected in numerous
neurodegenerative diseases including Alzheimer’s disease. These dysfunctions lead to …

VHH, bivalent domains and chimeric heavy chain-only antibodies with high neutralizing efficacy for scorpion toxin AahI′

…, D Saerens, Z Benlasfar, K Conrath, M El Ayeb… - Molecular …, 2008 - Elsevier
Many efforts aim at solving the serious problems encountered with immunotherapy against
scorpion envenoming. The most attractive approach consists in generating single-chain …

Snake venomics: Comparative analysis of the venom proteomes of the Tunisian snakes Cerastes cerastes, Cerastes vipera and Macrovipera lebetina

A Bazaa, N Marrakchi, M El Ayeb, L Sanz… - …, 2005 - Wiley Online Library
The protein composition of the crude venoms of the three most important vipers of Tunisia
was analyzed by RP‐HPLC, N‐terminal sequence analysis, MALDI‐TOF mass determination, …

A bispecific nanobody to provide full protection against lethal scorpion envenoming

…, N Abidi, Z Benlasfar, J Govaert, ME Ayeb… - The FASEB …, 2010 - Wiley Online Library
Envenoming following scorpion sting is a common emergency in many parts of the world.
Our aim was to ameliorate the current 100‐kDa horse plasma antivenom serum (PAS)‐derived …

Hemicalcin, a new toxin from the Iranian scorpion Hemiscorpius lepturus which is active on ryanodine-sensitive Ca2+ channels

…, IN Pessah, M De Waard, M El Ayeb - Biochemical …, 2007 - portlandpress.com
In the present work, we purified and characterized a novel toxin named hemicalcin from the
venom of the Iranian chactoid scorpion Hemiscorpius lepturus where it represents 0.6% of …

MVL-PLA2, a phospholipase A2 from Macrovipera lebetina transmediterranea venom, inhibits tumor cells adhesion and migration

…, C Defilles, JC Lissitzky, M El Ayeb… - Matrix Biology, 2009 - Elsevier
Here, we report the purification and characterization of an acidic Asp49 phospholipase A2,
named MVL-PLA2, with a molecular mass of 13,626.64 Da. The complete MVL-PLA2 cDNA …

[HTML][HTML] Antitumoral Potential of Tunisian Snake Venoms Secreted Phospholipases A2

…, N Srairi-Abid, A Bazaa, M El Ayeb… - BioMed Research …, 2013 - hindawi.com
Phospholipases type A 2 (PLA 2 s) are the most abundant proteins found in Viperidae
snake venom. They are quite fascinating from both a biological and structural point of view. …

[HTML][HTML] Disintegrin-like protein strategy to inhibit aggressive triple-negative breast cancer

I Limam, M Abdelkarim, M El Ayeb, M Crepin… - International journal of …, 2023 - mdpi.com
Mohamed El Ayeb … Limam, Inès, Mohamed Abdelkarim, Mohamed El Ayeb, Michel Crepin,
Naziha Marrakchi, and Mélanie Di Benedetto. 2023. "Disintegrin-like Protein Strategy to …

Two purified and characterized phospholipases A2 from Cerastes cerastes venom, that inhibit cancerous cell adhesion and migration

…, N Srairi-Abid, A Bazaa, E Loret, S Bezzine, M El Ayeb… - Toxicon, 2009 - Elsevier
Two non-toxic PLA2s were purified to homogeneity from Cerastes cerastes Tunisian snake
venom. The purification process employed gel filtration on Sephadex G-75 followed by C18 …

A new fold in the scorpion toxin family, associated with an activity on a ryanodine‐sensitive calcium channel

…, E Blanc, JM Sabatier, ME Ayeb… - Proteins: Structure …, 2000 - Wiley Online Library
We determined the structure in solution by 1 H two‐dimensional NMR of Maurocalcine from
the venom of Scorpio maurus. This toxin has been demonstrated to be a potent effector of …