One of the mechanisms that bacteria utilize to evade the toxic effects of antibiotics is the
active extrusion of structurally unrelated drugs from the cell. Both intrinsic and acquired …

… Ulrich Jäger, 1, 2 Michael Fridrik, 3 Markus Zeitlinger, 4 Daniel Heintel, 5 Georg
Hopfinger, 6 Sonja Burgstaller, 7 Christine Mannhalter, 8 Wilhelm Oberaigner, 9 Edit …

Lactococcus lactis possesses an ATP-binding cassette transporter, LmrA, which is a homolog
of the mammalian multidrug resistance (MDR) P-glycoprotein, and is able to transport a …

The secondary multidrug transporter LmrP of Lactococcus lactis mediates the efflux of Hoechst
33342 from the cytoplasmic leaflet of the membrane. Kinetic analysis of Hoechst 33342 …

The gene encoding the secondary multidrug transporter LmrP of Lactococcus lactis was
heterologously expressed in Escherichia coli. The energetics and mechanism of drug extrusion …

The active efflux of toxic compounds by (multi)drug transporters is one of the mechanisms
that bacteria have developed to resist cytotoxic drugs. The authors describe the role of the …

The histidine-tagged secondary multidrug transporter LmrP was overexpressed in Lactococcus
lactis, using a novel protein expression system for cytotoxic proteins based on the tightly …

The active extrusion of cytotoxic compounds from the cell by multidrug transporters is one of
the major causes of failure of chemotherapeutic treatment of tumor cells and of infections by …

LmrA is a 590-amino acid membrane protein which confers multidrug resistance on Lactococcus
lactis cells by extruding amphiphilic compounds from the inner leaflet of the cytoplasmic …

Multidrug resistance presents a major obstacle to the treatment of infectious diseases and
cancer. LmrA, a bacterial ATP-dependent multidrug transporter, mediates efflux of …